While small-scale farming households constitute a large part of the population, as well as the producers of the majority of food supplies in low- and middle-income countries, major gaps remain in the ability to produce reliable solutions to achieve sustainability in family farming. This special issue aims to address some blind spots and shed new light on sustainability in family farming using sustainability science. The publications presented in this special issue will enable readers to grasp the importance of a detailed and situated understanding of the needs and practices of family farming, as well as the importance of involving farmers and their families in our research to find solutions for improving the sustainability of family farming that will benefit everyone.