Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue The World Journal of Men's Health Année : 2022

Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices

Sajal Gupta (1) , Rakesh Sharma (1) , Ashok Agarwal (1) , Florence Boitrelle (2, 3) , Renata Finelli (1) , Ala'A Farkouh (1) , Ramadan Saleh (4) , Taha Abo-Almagd Abdel-Meguid (5, 6) , Murat Gül (7) , Birute Zilaitiene (8) , Edmund Ko (9) , Amarnath Rambhatla (10) , Armand Zini (11) , Kristian Leisegang (12) , Shinnosuke Kuroda (1) , Ralf Henkel (1, 13, 12) , Rossella Cannarella (14) , Ayad Palani (15) , Chak-Lam Cho (16) , Christopher C.K. Ho (17) , Daniel Suslik Zylbersztejn (18) , Edoardo Pescatori , Eric Chung (19) , Fotios Dimitriadis (20) , Germar-Michael Pinggera (21) , Gian Maria Busetto (22) , Giancarlo Balercia (23) , Gianmaria Salvio (23) , Giovanni M Colpi , Gökhan Çeker , Hisanori Taniguchi (24) , Hussein Kandil (25) , Hyun Jun Park (26) , Israel Maldonado Rosas , Jean de la Rosette (27) , Joao Paulo Greco Cardoso (28) , Jonathan Ramsay (29) , Juan Alvarez (30) , Juan Manuel Corral Molina , Kareim Khalafalla (31, 32) , Kasonde Bowa (33) , Kelton Tremellen (34) , Evangelini Evgeni , Lucia Rocco (35) , Marcelo Gabriel Rodriguez Peña , Marjan Sabbaghian (36) , Marlon Martinez (37) , Mohamed Arafa (1, 31, 38) , Mohamed S Al-Marhoon (39) , Nicholas Tadros (40) , Nicolas Garrido , Osvaldo Rajmil (41) , Pallav Sengupta , Paraskevi Vogiatzi , Parviz Kavoussi (42) , Ponco Birowo (43) , Raghavender Kosgi , Saleem Bani-Hani (44) , Sava Micic , Sijo Parekattil , Sunil Jindal , Tan V Le , Taymour Mostafa (45) , Tuncay Toprak (46) , Yoshiharu Morimoto , Vineet Malhotra , Azin Aghamajidi (47) , Damayanthi Durairajanayagam (48) , Rupin Shah (49)
1 Cleveland Clinic
2 CHI Poissy-Saint-Germain
3 BREED - Biologie de la Reproduction, Environnement, Epigénétique & Développement
4 Sohag University
5 Minia University
6 KAU - King Abdul Aziz University
7 Selçuk University = Selçuk Üniversitesi
8 LUSH - Lithuanian University of Health Science
9 Loma Linda University
10 Vattikuti Urology Institute
11 McGill University = Université McGill [Montréal, Canada]
12 UWC - University of the Western Cape
13 Imperial College London
14 Unict - Università degli studi di Catania = University of Catania
15 University of Garmian
16 CUHK - The Chinese University of Hong Kong [Hong Kong]
17 Taylor’s University
18 Hospital Israelita Albert Einstein [São Paulo, Brazil]
19 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
20 Aristotle University of Thessaloniki
21 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
22 Unifg - Università degli Studi di Foggia = University of Foggia
23 UNIVPM - Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia]
24 Kansai Medical University
25 Fakih IVF Fertility Center
26 PNU - Pusan National University
27 Istanbul Medipol University
28 USP - Universidade de São Paulo = University of São Paulo
29 Hammersmith Hospital NHS Imperial College Healthcare
30 HMS - Harvard Medical School [Boston]
31 Hamad Medical Corporation [Doha, Qatar]
32 UIC - University of Illinois [Chicago]
33 UNZA - University of Zambia [Lusaka]
34 Flinders University of South Australia
35 Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli
36 Royan Institute for Reproductive Biomedicine [Tehran, Iran]
37 University of Santo Tomas [Manila, Philippines]
38 Weill Cornell Medicine [Qatar]
39 SQU - Sultan Qaboos University
40 University of Illinois [Springfield]
41 Fundació Puigvert [Barcelona, Spain]
42 University of Texas Health Science Center at San Antonio [San Antonio, Tx, USA]
43 Cipto Mangunkusumo Hospital [Jakarta]
44 JUST - Jordan University of Science and Technology [Irbid, Jordan]
45 Cairo University
46 University of Health Sciences,Istanbul,Turkey
47 IUMS - Iran University of Medical Sciences [Tehran, Iran]
48 UiTM - Universiti Teknologi MARA [Shah Alam]
49 Lilavati Hospital and Research Centre
Sajal Gupta
Cleveland Clinic
Rakesh Sharma
Cleveland Clinic
Ashok Agarwal
Cleveland Clinic
Florence Boitrelle
CHI Poissy-Saint-Germain
Biologie de la Reproduction, Environnement, Epigénétique & Développement
CV
Renata Finelli
Cleveland Clinic
Ala'A Farkouh
Cleveland Clinic
Ramadan Saleh
Sohag University
Taha Abo-Almagd Abdel-Meguid
Minia University
King Abdul Aziz University
Murat Gül
Selçuk University = Selçuk Üniversitesi
Birute Zilaitiene
Lithuanian University of Health Science
Edmund Ko
Loma Linda University
Amarnath Rambhatla
Vattikuti Urology Institute
Armand Zini
McGill University = Université McGill [Montréal, Canada]
Kristian Leisegang
University of the Western Cape
Shinnosuke Kuroda
Cleveland Clinic
Ralf Henkel
Cleveland Clinic
Imperial College London
University of the Western Cape
Rossella Cannarella
Università degli studi di Catania = University of Catania
Ayad Palani
University of Garmian
Chak-Lam Cho
The Chinese University of Hong Kong [Hong Kong]
Christopher C.K. Ho
Taylor’s University
Daniel Suslik Zylbersztejn
Hospital Israelita Albert Einstein [São Paulo, Brazil]
Edoardo Pescatori
Eric Chung
The University of Queensland
Fotios Dimitriadis
Aristotle University of Thessaloniki
Germar-Michael Pinggera
Innsbruck Medical University = Medizinische Universität Innsbruck
Gian Maria Busetto
Università degli Studi di Foggia = University of Foggia
Giancarlo Balercia
Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia]
Gianmaria Salvio
Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia]
Giovanni M Colpi
Gökhan Çeker
Hisanori Taniguchi
Kansai Medical University
Hussein Kandil
Fakih IVF Fertility Center
Hyun Jun Park
Pusan National University
Israel Maldonado Rosas
Jean de la Rosette
Istanbul Medipol University
Joao Paulo Greco Cardoso
Universidade de São Paulo = University of São Paulo
Jonathan Ramsay
Hammersmith Hospital NHS Imperial College Healthcare
Juan Alvarez
Harvard Medical School [Boston]
Juan Manuel Corral Molina
Kareim Khalafalla
Hamad Medical Corporation [Doha, Qatar]
University of Illinois [Chicago]
Kasonde Bowa
University of Zambia [Lusaka]
Kelton Tremellen
Flinders University of South Australia
Evangelini Evgeni
Lucia Rocco
Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli
Marcelo Gabriel Rodriguez Peña
Marjan Sabbaghian
Royan Institute for Reproductive Biomedicine [Tehran, Iran]
Marlon Martinez
University of Santo Tomas [Manila, Philippines]
Mohamed Arafa
Cleveland Clinic
Hamad Medical Corporation [Doha, Qatar]
Weill Cornell Medicine [Qatar]
Mohamed S Al-Marhoon
Sultan Qaboos University
Nicholas Tadros
University of Illinois [Springfield]
Nicolas Garrido
Osvaldo Rajmil
Fundació Puigvert [Barcelona, Spain]
Pallav Sengupta
Paraskevi Vogiatzi
Parviz Kavoussi
University of Texas Health Science Center at San Antonio [San Antonio, Tx, USA]
Ponco Birowo
Cipto Mangunkusumo Hospital [Jakarta]
Raghavender Kosgi
Saleem Bani-Hani
Jordan University of Science and Technology [Irbid, Jordan]
Sava Micic
Sijo Parekattil
Sunil Jindal
Tan V Le
Taymour Mostafa
Cairo University
Tuncay Toprak
University of Health Sciences,Istanbul,Turkey
Yoshiharu Morimoto
Vineet Malhotra
Azin Aghamajidi
Iran University of Medical Sciences [Tehran, Iran]
Damayanthi Durairajanayagam
Universiti Teknologi MARA [Shah Alam]
Rupin Shah
Lilavati Hospital and Research Centre

Résumé

Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are due to an abnormal exposure of mature germ cells to the immune system. ASA testing (with mixed anti-globulin reaction, and immunobead binding test) was described in the WHO manual 5th edition and is most recently listed among the extended semen tests in the WHO manual 6th edition. The relationship between ASA and infertility is somewhat complex. The presence of sperm agglutination, while insufficient to diagnose immunological infertility, may indicate the presence of ASA. However, ASA can also be present in the absence of any sperm agglutination. The andrological management of ASA depends on the etiology and individual practices of clinicians. In this article, we provide a comprehensive review of the causes of ASA production, its role in immunological male infertility, clinical indications of ASA testing, and the available therapeutic options. We also provide the details of laboratory procedures for assessment of ASA together with important measures for quality control. Additionally, laboratory and clinical scenarios are presented to guide the reader in the management of ASA and immunological male infertility. Furthermore, we report the results of a recent worldwide survey, conducted to gather information about clinical practices in the management of immunological male infertility.

Domaines

Biologie de la reproduction
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Soumis le : mardi 23 janvier 2024-15:22:23

Dernière modification le : lundi 15 avril 2024-13:26:03

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hal-04412625 , version 1 (23-01-2024)

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Sajal Gupta, Rakesh Sharma, Ashok Agarwal, Florence Boitrelle, Renata Finelli, et al.. Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices. The World Journal of Men's Health, 2022, 40 (3), pp. 380. ⟨10.5534/wjmh.210164⟩. ⟨hal-04412625⟩

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