Genome-wide association studies reveal novel loci for resistance to groundnut rosette disease in the African core groundnut collection - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles TAG Theoretical and Applied Genetics Year : 2023

Genome-wide association studies reveal novel loci for resistance to groundnut rosette disease in the African core groundnut collection

Abstract

Groundnut is cultivated in several African countries where it is a major source of food, feed and income. One of the major constraints to groundnut production in Africa is groundnut rosette disease (GRD), which is caused by a complex of three agents: groundnut rosette assistor luteovirus, groundnut rosette umbravirus and its satellite RNA. Despite several years of breeding for GRD resistance, the genetics of the disease is not fully understood. The objective of the current study was to use the African core collection to establish the level of genetic variation in their response to GRD, and to map genomic regions responsible for the observed resistance. The African groundnut core genotypes were screened across two GRD hotspot locations in Uganda (Nakabango and Serere) for 3 seasons. The Area Under Disease Progress Curve combined with 7523 high quality SNPs were analyzed to establish marker-trait associations (MTAs). Genome-Wide Association Studies based on Enriched Compressed Mixed Linear Model detected 32 MTAs at Nakabango: 21 on chromosome A04, 10 on B04 and 1 on B08. Two of the significant markers were localised on the exons of a putative TIR-NBS-LRR disease resistance gene on chromosome A04. Our results suggest the likely involvement of major genes in the resistance to GRD but will need to be further validated with more comprehensive phenotypic and genotypic datasets. The markers identified in the current study will be developed into routine assays and validated for future genomics-assisted selection for GRD resistance in groundnut. Communicated by Dechun Wang.
Fichier principal
Vignette du fichier
2023-Theoretical-Achola.pdf (10.31 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive
Licence

Dates and versions

hal-04477315 , version 1 (26-02-2024)

Licence

Identifiers

Cite

Esther Achola, Peter Wasswa, Daniel Fonceka, Josh Paul Clevenger, Prasad Bajaj, et al.. Genome-wide association studies reveal novel loci for resistance to groundnut rosette disease in the African core groundnut collection. TAG Theoretical and Applied Genetics, 2023, 136 (3), pp.35. ⟨10.1007/s00122-023-04259-4⟩. ⟨hal-04477315⟩
10 View
1 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More