Summary Micro‐RNAs have emerged as important actors in the onset of metabolic disorders including obesity or type 2 diabetes. Particularly, several micro‐RNAs are known to be key modulators of lipid metabolism, glucose homeostasis, or feeding behavior. Interestingly, the role of extracellular vesicles containing micro‐RNAs, especially adipose‐derived extracellular vesicles, are well‐documented endocrine signals and disease biomarkers. However, the role of adipose‐derived extracellular vesicles on the different tissues is different and highly related to the micro‐RNA content. This review provides recent data about the potential involvement of adipose‐derived extracellular vesicle‐containing micro‐RNAs in metabolic diseases.