Sequence-based GWAS of heat tolerance traits in Holstein and Montbeliarde cattle. - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Conference Papers Year : 2024

Sequence-based GWAS of heat tolerance traits in Holstein and Montbeliarde cattle.

Abstract

Global warming will affect European cattle production systems, decreasing overall performance and welfare. In such a context, it is thus relevant to identify genomic regions involved in heat tolerance for production and functional traits. By combining the French bovine genetic database (focusing on French Holstein and Montbéliarde dairy cattle) with weather conditions (Safran database, Meteo-France), we estimated breeding values (BV) of animals along a temperature-humidity index (THI) gradient with a reaction-norm model. Heat tolerance traits were defined as the slope of BV at THI 70 for three traits: test-day milk yield, conception rate at first insemination, and somatic cell score. 50K SNPs from 4564 Holstein and 1737 Montbéliarde bulls were imputed to whole genome sequence using the run9 of the 1000 bull genomes project, resulting in ~13 million SNPs (R2 Minimac ≥ 0.2 and MAF ≥ 0.01) to perform within-breed GWAS of heat tolerance for the three traits. Few genomic regions were significantly associated with heat tolerance, however these regions differed between breeds and traits. Beyond revealing novel regions associated to heat tolerance, our study also identified some regions already reported in previous studies, emphasizing their relevance. Finally, given the genetic background of heat tolerance in both production and functional traits, selection for heat tolerance should be considered. This study received funding from the European Union’s Horizon 2020 research and innovation program under grant number 101000226 (Rumigen) and from APIS-GENE (CAICalor). The authors thank Meteo-France for the Safran database.

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Animal genetics
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Dates and versions

hal-04694182 , version 1 (11-09-2024)

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  • HAL Id : hal-04694182 , version 1

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Aurélie Vinet, Sophie Mattalia, Vallée Roxane, Anne Barbat, Christine Bertrand, et al.. Sequence-based GWAS of heat tolerance traits in Holstein and Montbeliarde cattle.. 75th Annual Meeting of the European Federation of Animal Science, EAAP, Sep 2024, Florence, Italy. ⟨hal-04694182⟩
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