MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Mitja M Zdouc
(1)
,
Kai Blin
(2)
,
Nico L Louwen
(1)
,
Jorge Navarro
(1)
,
Catarina Loureiro
(1)
,
Chantal D Bader
(3)
,
Constance B Bailey
(4)
,
Lena Barra
(5)
,
Thomas J Booth
(2)
,
Kenan A Bozhüyük
(3, 6)
,
José D Cediel-Becerra
(7)
,
Zachary Charlop-Powers
(8)
,
Marc G Chevrette
(7, 9)
,
Yit Heng Chooi
(10)
,
Paul M D’agostino
(3, 11)
,
Tristan de Rond
(12)
,
Elena del Pup
(1)
,
Katherine R Duncan
(13)
,
Wenjia Gu
(14)
,
Novriyandi Hanif
(15)
,
Eric J Helfrich
(16, 17, 18)
,
Matthew Jenner
(19, 20)
,
Yohei Katsuyama
(21, 22)
,
Aleksandra Korenskaia
(23)
,
Daniel Krug
(3, 24, 25)
,
Vincent Libis
(26, 27)
,
George A Lund
(28)
,
Shrikant Mantri
(29, 30)
,
Kalindi D Morgan
(31)
,
Charlotte Owen
(32)
,
Chin-Soon Phan
(33)
,
Benjamin Philmus
(34)
,
Zachary L Reitz
(35)
,
Serina L Robinson
(36)
,
Kumar Saurabh Singh
(1, 37, 38)
,
Robin Teufel
(39)
,
Yaojun Tong
(40)
,
Fidele Tugizimana
(41, 42)
,
Dana Ulanova
(43, 44)
,
Jaclyn M Winter
(45)
,
César Aguilar
(46, 47)
,
Daniel Y Akiyama
(48)
,
Suhad A Al-Salihi
(49)
,
Mohammad Alanjary
(1)
,
Fabrizio Alberti
(50)
,
Gajender Aleti
(51)
,
Shumukh A Alharthi
(52)
,
Mariela y Arias Rojo
(53)
,
Amr A Arishi
(10, 54)
,
Hannah E Augustijn
(1, 55)
,
Nicole E Avalon
(56)
,
J Abraham Avelar-Rivas
(57)
,
Kyle K Axt
(34)
,
Hellen B Barbieri
(48)
,
Julio Cesar J Barbosa
(48)
,
Lucas Gabriel Barboza Segato
(58)
,
Susanna E Barrett
(59, 60)
,
Martin Baunach
(61)
,
Christine Beemelmanns
(3, 24)
,
Dardan Beqaj
(62)
,
Tim Berger
(63)
,
Jordan Bernaldo-Agüero
(64, 65)
,
Sandra M Bettenbühl
(16, 17)
,
Vincent A Bielinski
(66)
,
Friederike Biermann
(1, 16, 17)
,
Ricardo M Borges
(67)
,
Rainer Borriss
(68, 69)
,
Milena Breitenbach
(16, 17)
,
Kevin M Bretscher
(55, 70, 71)
,
Michael W Brigham
(72)
,
Larissa Buedenbender
(73)
,
Brodie W Bulcock
(10)
,
Carolina Cano-Prieto
(2)
,
João Capela
(74)
,
Victor J Carrion
(55, 70, 75)
,
Riley S Carter
(59, 60)
,
Raquel Castelo-Branco
(76)
,
Gabriel Castro-Falcón
(56)
,
Fernanda O Chagas
(67)
,
Esteban Charria-Girón
(25, 77)
,
Ayesha Ahmed Chaudhri
(16, 17)
,
Vasvi Chaudhry
(78)
,
Hyukjae Choi
(79, 80)
,
Yukyung Choi
(81)
,
Roya Choupannejad
(82)
,
Jakub Chromy
(83)
,
Melinda S Chue Donahey
(7)
,
Jérôme Collemare
(82)
,
Jack A Connolly
(83)
,
Kaitlin E Creamer
(84, 85)
,
Max Crüsemann
(61)
,
Andres Arredondo Cruz
(53)
,
Andres Cumsille
(7)
,
Jean-Felix Dallery
(86)
,
Luis Caleb Damas-Ramos
(2)
,
Tito Damiani
(87)
,
Martinus de Kruijff
(3)
,
Belén Delgado Martín
(75)
,
Gerardo Della Sala
(88)
,
Jelle Dillen
(89)
,
Drew T Doering
(90)
,
Shravan R Dommaraju
(59, 60)
,
Suhan Durusu
(16, 17)
,
Susan Egbert
(58)
,
Mark Ellerhorst
(91)
,
Baptiste Faussurier
(26, 27)
,
Artem Fetter
(13)
,
Marc Feuermann
(92)
,
David P Fewer
(93)
,
Jonathan Foldi
(83)
,
Andri Frediansyah
(94, 95)
,
Erin A Garza
(96)
,
Athina Gavriilidou
(23)
,
Andrea Gentile
(97, 98)
,
Jennifer Gerke
(99)
,
Hans Gerstmans
(100, 101, 102)
,
Juan Pablo Gomez-Escribano
(103)
,
Luz A González-Salazar
(46)
,
Natalie E Grayson
(56)
,
Claudio Greco
(52)
,
Juan E Gris Gomez
(46)
,
Sebastian Guerra
(7, 9)
,
Shaday Guerrero Flores
(104)
,
Alexey Gurevich
(3, 24)
,
Karina Gutiérrez-García
(105)
,
Lauren Hart
(106, 107)
,
Kristina Haslinger
(108)
,
Beibei He
(109)
,
Teo Hebra
(87)
,
Jethro L Hemmann
(110)
,
Hindra Hindra
(111, 112)
,
Lars Höing
(39)
,
Darren C Holland
(10)
,
Jonathan E Holme
(113)
,
Therese Horch
(2)
,
Pavlo Hrab
(1, 114)
,
Jie Hu
(115)
,
Thanh-Hau Huynh
(116)
,
Ji-Yeon Hwang
(117)
,
Riccardo Iacovelli
(118)
,
Dumitrita Iftime
(62)
,
Marianna Iorio
(97)
,
Sidharth Jayachandran
(2)
,
Eunah Jeong
(81)
,
Jiayi Jing
(1)
,
Jung J Jung
(116)
,
Yuya Kakumu
(16, 17)
,
Edward Kalkreuter
(119)
,
Kyo Bin Kang
(81)
,
Sangwook Kang
(116)
,
Wonyong Kim
(120)
,
Geum Jin Kim
(80, 121)
,
Hyunwoo Kim
(122)
,
Hyun Uk Kim
(123)
,
Martin Klapper
(124)
,
Robert A Koetsier
(1)
,
Cassandra Kollten
(11)
,
Ákos T Kovács
(55, 125)
,
Yelyzaveta Kriukova
(3, 11)
,
Noel Kubach
(23)
,
Aditya M Kunjapur
(126)
,
Aleksandra K Kushnareva
(3, 24)
,
Andreja Kust
(84, 85)
,
Jessica Lamber
(3, 24, 127)
,
Martin Larralde
(128)
,
Niels J Larsen
(2)
,
Adrien P Launay
(129)
,
Ngoc-Thao-Hien Le
(26)
,
Sarah Lebeer
(89, 130)
,
Byung Tae Lee
(123)
,
Kyungha Lee
(81)
,
Katherine L Lev
(106, 107)
,
Shu-Ming Li
(63)
,
Yong-Xin Li
(109)
,
Cuauhtémoc Licona-Cassani
(46, 131)
,
Annette Lien
(1)
,
Jing Liu
(109)
,
Julius Adam V Lopez
(132, 133)
,
Nataliia V Machushynets
(55)
,
Marla I Macias
(134)
,
Taifo Mahmud
(34)
,
Matiss Maleckis
(135)
,
Añadir Maharai Martinez-Martinez
(46)
,
Yvonne Mast
(103, 136)
,
Marina F Maximo
(48)
,
Christina M Mcbride
(106, 107)
,
Rose M Mclellan
(137, 138)
,
Khyati Mehta Bhatt
(82)
,
Chrats Melkonian
(1, 139)
,
Aske Merrild
(140)
,
Mikko Metsä-Ketelä
(141)
,
Douglas A Mitchell
(59)
,
Alison V Müller
(3, 24, 127)
,
Giang-Son Nguyen
(113)
,
Hera T Nguyen
(10)
,
Timo H J Niedermeyer
(142)
,
Julia H O’hare
(67)
,
Adam Ossowicki
(70, 75)
,
Bohdan O Ostash
(143, 144)
,
Hiroshi Otani
(90, 145)
,
Leo Padva
(61)
,
Sunaina Paliyal
(29)
,
Xinya Pan
(55, 70, 71)
,
Mohit Panghal
(29, 30)
,
Dana Parade
(3)
,
Jiyoon Park
(116)
,
Jonathan Parra
(146, 147, 148)
,
Marcos Pedraza Rubio
(70, 75)
,
Huong T Pham
(81)
,
Sacha J Pidot
(149)
,
Jörn Piel
(150)
,
Bita Pourmohsenin
(23)
,
Malik Rakhmanov
(39)
,
Sangeetha Ramesh
(151)
,
Michelle H Rasmussen
(152)
,
Adriana Rego
(76)
,
Raphael Reher
(63)
,
Andrew J Rice
(59)
,
Augustin Rigolet
(55)
,
Adriana Romero-Otero
(2, 135)
,
Luis Rodrigo Rosas-Becerra
(55, 57)
,
Pablo Y Rosiles
(129)
,
Adriano Rutz
(153)
,
Byeol Ryu
(56)
,
Libby-Ann Sahadeo
(58)
,
Murrel Saldanha
(7)
,
Luca Salvi
(62)
,
Eduardo Sánchez-Carvajal
(154)
,
Christian Santos-Medellin
(115)
,
Nicolau Sbaraini
(10)
,
Sydney M Schoellhorn
(155)
,
Clemens Schumm
(3, 127, 156)
,
Ludek Sehnal
(62, 157)
,
Nelly Selem
(104)
,
Anjali D Shah
(158, 159)
,
Tania K Shishido
(82, 160)
,
Simon Sieber
(161)
,
Velina Silviani
(79, 80)
,
Garima Singh
(162, 163)
,
Hemant Singh
(29)
,
Nika Sokolova
(108)
,
Eva C Sonnenschein
(52)
,
Margherita Sosio
(97)
,
Sven T Sowa
(39)
,
Karin Steffen
(164)
,
Evi Stegmann
(62, 165)
,
Alena B Streiff
(150)
,
Alena Strüder
(62)
,
Frank Surup
(25, 77)
,
Tiziana Svenningsen
(140)
,
Douglas Sweeney
(56)
,
Judit Szenei
(2)
,
Azat Tagirdzhanov
(3, 24)
,
Bin Tan
(16, 17)
,
Matthew J Tarnowski
(52)
,
Barbara R Terlouw
(1)
,
Thomas Rey
(166, 167)
,
Nicola U Thome
(55, 168)
,
Laura Rosina Torres Ortega
(1)
,
Thomas Tørring
(140)
,
Marla Trindade
(169)
,
Andrew W Truman
(170)
,
Marie Tvilum
(140)
,
Daniel W Udwary
(90)
,
Christoph Ulbricht
(61)
,
Lisa Vader
(2)
,
Gilles P van Wezel
(55, 71)
,
Max Walmsley
(83)
,
Randika Warnasinghe
(58)
,
Heiner G Weddeling
(39)
,
Angus N Weir
(100, 171)
,
Katherine Williams
(158, 172)
,
Sam E Williams
(2)
,
Thomas E Witte
(173)
,
Steffaney M Wood Rocca
(56, 96)
,
Keith Yamada
(141)
,
Dong Yang
(174)
,
Dongsoo Yang
(175)
,
Jingwei Yu
(176)
,
Zhenyi Zhou
(177)
,
Nadine Ziemert
(23)
,
Lukas Zimmer
(61)
,
Alina Zimmermann
(103)
,
Christian Zimmermann
(178)
,
Justin J van der Hooft
(1, 41)
,
Roger G Linington
(179)
,
Tilmann Weber
(2)
,
Marnix H Medema
(1)
1
WUR -
Wageningen University and Research [Wageningen]
2 Novo Nordisk Foundation Center for Biosustainability
3 HIPS - Helmholtz Institute for Pharmaceutical Research Saarland
4 UNSW School of Chemistry [Sydney]
5 Univ Konstanz, Dept. Chemistry
6 Myria Biosciences AG
7 Dept. Microbiology and Cell Science, University of Florida
8 Ginkgo Bioworks [Boston, MA, États-Unis]
9 UFGI - University of Florida Genetics Institute
10 School of Molecular Sciences, The University of Western Australia, Perth 6009, Australia
11 Chair of Technical Biochemistry, Technical Université of Dresden
12 School of Chemical Sciences [Auckland]
13 Biosciences Institute, Faculty of Medical Sciences [Newcastle]
14 Sutro Biopharma, South San Francisco
15 Bogor Agricultural University - IPB (INDONESIA)
16 Goethe University Frankfurt
17 LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG)
18 Senckenberg Society for Nature Research
19 Department of Chemistry [University of Warwick]
20 WISB - Warwick Integrative Synthetic Biology Centre
21 Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
22 Collaborative Research institute for Innovative Microbiology, University of Tokyo
23 Translational Genome Mining for Natural Products, University of Tübingen
24 Universität des Saarlandes [Saarbrücken] = Saarland University [Saarbrücken]
25 HZI - Helmholtz Centre for Infection Research
26 UPCité - Université Paris Cité
27 Generare Bioscience [Paris]
28 Rothamsted Research - Department of Soil Science, Harpenden, Royaume Uni
29 computational biology lab, National Agri-food and Biomanufacturing Institute, Punjab
30 Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad
31 UNBC - University of Northern British Columbia [Prince George]
32 Department of Biochemistry and Metabolism, Department of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, United Kingdom
33 Latvian Institute of Organic Synthesis [Riga, Lituania]
34 Department of Pharmaceutical Sciences, Oregon State University
35 Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara
36 Department of Environmental Microbiology, Swiss Federal Institute of Aquatic Science and Technology
37 Plant-Microbe Interactions, Institute of Environmental Biologyutrecht
38 Faculty of Environment, Science and Economy, University of Exeter
39 Department of Pharmaceutical Sciences, University of Basel
40 State Key Laboratory of Microbial Metabolism
41 Department of Biochemistry, University of Johannesburg
42 Omnia Nutriology, Sandton
43 Department of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University
44 Center for Advanced Marine Core Research
45 Department of pharmacology and toxicology, University of Utah
46 Industrial Genomics Laboratory, FEMSA, México
47 Purdue University [West Lafayette]
48 Institute of Chemistry, UNICAMP
49 Department of Applied Sciences, University of Technology, Baghdad
50 School of Life Sciences [Warwick]
51 Department of Food and Animal Sciences, Tennessee State University
52 SWANSEA UNIVERSITY DEPARTMENT OF BIOSCIENCES SWANSEA GBR
53 Escuela Nacional de Estudios Superiores Unidad Léon, Mexico
54 Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
55 IBL - Institute Biology Leiden
56 Center for Marine Biotechnology and Biomedicine
57 IPN - Instituto Politecnico Nacional [Mexico]
58 Department of Chemistry, University of Manitoba
59 Department of Chemistry, University of Illinois Urbana-Champaign
60 Carl R. Woese Institute of Genomic Biology
61 Institute of Pharmaceutical Biology, University of Bonn
62 Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine
63 Institute of Pharmaceutical Biology and Biotechnology, University of Marburg
64 Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico
65 UNMSM - Universidad Nacional Mayor de San Marcos
66 UFRJ - Universidade Federal do Rio de Janeiro [Brasil] = Federal University of Rio de Janeiro [Brazil] = Université fédérale de Rio de Janeiro [Brésil]
67 Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro
68 HU Berlin - Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin
69 Universität Greifswald - University of Greifswald
70 Department of Crop Protection, Instituto de Hortofructicultura Subtropical y Mediterránea, Málaga
71 Department of Microbial Ecology, NIOO-KNAW
72 School of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Leeds
73 Centro Interdisciplinar de Química e Bioloxía, Universidade de Coruña
74 Centre of Biological Engineering, University of Minho
75 Universidad de Málaga [Málaga] = University of Málaga [Málaga]
76 CIMAR - Interdisciplinary Center of Marine and Environmental Research
77 Institute of Microbiology, Technical University of Braunschweig
78 ZMBP - Zentrum für Molekularbiologie der Pflanzen
79 Yeungnam University [South Korea]
80 Research Institute of Cell Culture, Yeungnam University
81 College of Pharmacy and Drug Information Research Institute, Sookmyung Women’s University
82 Fungal Natural Products, Westerdijk Fungal Biodiversity Institute
83 Manchester Institute of Biotechnology
84 Innovative Genomics Institute
85 EPS - Department of Earth and Planetary Science [UC Berkeley]
86 BIOGER - BIOlogie et GEstion des Risques en agriculture
87 IOCB / CAS - Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
88 SZN - Stazione Zoologica Anton Dohrn
89 Department of Biosciences Engineering, University of Antwerp
90 US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA
91 Biochemistry of Microorganisms, Faculty of Life Sciences: Food, Nutrition, and Health, University of Bayreuth, Kulmbach
92 SIB - Swiss Institute of Bioinformatics [Genève]
93 Department of Applied Chemistry and Microbiology [Helsinki]
94 Research Center for Food Technology and Processing, National Research and Innovation Agency, Indonesia
95 BRIN - National Research and Innovation Agency
96 JCVI - J. Craig Venter Institute [La Jolla, USA]
97 NAICONS Srl, viale Ortles 22/4, Milan
98 Department of Chemistry, University of Parma
99 Leibniz Universität Hannover=Leibniz University Hannover
100 VIB-KU Leuven Center for Microbiology [Leuven, Belgium]
101 Department of Biology, Laboratory for Biomolecular Discovery & Engineering, KU Leuven
102 BIOSYST - Department of Biosystems
103 Leibniz-Institut Deutsche Sammlung von Mikroorganismen und Zelllkulturen GmBH - DSMZ (GERMANY)
104 UNAM - Instituto de Matematicas
105 Carnegie Institution for Science
106 Interdepartmental Program in Chemical Biology, University of Michigan
107 Life Sciences Institute [Ann Arbor, MI, USA]
108 University of Groningen [Groningen]
109 Department of Chemistry, The University of Hong Kong
110 Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute)
111 Institute of Infectious Disease Research, McMaster University, Ontario
112 McMaster University Hamilton - Department of Biology
113 SINTEF Industry
114 Microbiology Group, Wageningen University & Research
115 Corteva agriscience
116 Natural Products Research Institute, College of Pharmacy, Seoul National University
117 Center for Cancer Research, National Cancer Institute, Maryland
118 VTT - VTT Technical Research Centre of Finland
119 DCB - Department of Chemistry and Biochemistry, Florida State University, Chieftain Way, Tallahassee, Florida, USA
120 Department of Applied Biology, College of Agricultural and Life Sciences, Chonnam National University, Gwangju
121 Department of Pharmacology, College of Medicine, Dongguk University
122 College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University
123 Department of Biological Sciences, KAIST, Daejeon
124 Department of Paleobiotechnology, Hans Knöll Institute, Jena
125 DTU Bioengineering
126 Department of Chemical and Biomolecular Engineering, University of Delaware
127 DZIF - German Center for Infection Research - partner site Hannover-Braunschweig
128 LUMC - Leiden University Medical Center
129 Endogenomiks, Querétaro, Mexico
130 U-MaMi Centre of Excellence, Antwerp
131 Integrative Biology Research Unit, The Institute of Obesity Research, México
132 School of innovation and Sustainability,De La Salle University, Laguna
133 Department of Chemistry, De La Salle University, Manila
134 University of Strathclyde [Glasgow]
135 Department of Biotechnology and Biomedicine
136 Technical University of Braunschweig, Institute of Microbiology
137 The Ferrier Research Institute
138 Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
139 Department of Biology, Faculty of Sciences, Utrecht University
140 Department of Biological and Chemical Engineering, Aarhus University
141 University of Turku
142 Freie Universität Berlin
143 Ivan Franko National University of Lviv
144 German-Ukrainian Core of Excellence in Natural Products Research, Lviv
145 EGSB - Environmental Genomics and Systems Biology Division [LBNL Berkeley]
146 CIPRONA - Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica
147 Cenibiot - Centro Nacional de Innovaciones Biotecnologicas
148 INIFAR - Instituto de Investigaciones Farmacéuticas, Universidad de Costa Rica
149 Doherty Institute, University of Melbourne
150 Institute of Microbiology [Zurich]
151 Davis Department of Plant Pathology
152 Department of Chemistry [Aarhus]
153 IMSB - Institute for Molecular Systems Biology [ETH Zurich]
154 Laboratorio de Microbiologia Molecular y Biotecnologia Ambiantal, Centro de Biotecnologia DAL, Universidad Tecnica Federico Santa Maria, Valparaiso
155 Department of Chemistry and BioDiscovery Institute, University of North Texas
156 HZI - Helmholtz Center for Infection Research [Braunschweig, Germany]
157 RECETOX / MUNI - Research Centre for Toxic Compounds in the Environment [Brno]
158 School of Biological Sciences [Bristol]
159 School of Chemistry, University of Bristol
160 HiLIFE - Helsinki Institute of Life Science
161 Department of Chemistry, University of Zurich
162 Department of Biology, University of Padova
163 Botanical Garden, University of Padova
164 Department of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University
165 DZIF - German Center for Infectious Research - partner site Tübingen [Tübingen, Allemagne]
166 Groupe De Sangosse
167 LRSV - Laboratoire de Recherche en Sciences Végétales
168 Department of Biology, Laboratory of Biomolecular Discovery & Engineering, KU Leuven
169 IMBM - Institute for Microbial Biotechnology and Metagenomics [Cape Town, South Africa]
170 JIC - Department of Molecular Microbiology John Innes Centre
171 Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford
172 School of Applied Sciences, University of the West of England, Bristol
173 Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada
174 Natural Products Discovery Center, The Herbert Wertheim, Florida
175 Synthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering, Korea University, Seoul
176 Institute of Plant and Food Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China
177 College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals
178 Institute of Chemical, Environmental and Biological Engineering
179 [SFU.ca] - Department of Chemistry [Simon Fraser University]
2 Novo Nordisk Foundation Center for Biosustainability
3 HIPS - Helmholtz Institute for Pharmaceutical Research Saarland
4 UNSW School of Chemistry [Sydney]
5 Univ Konstanz, Dept. Chemistry
6 Myria Biosciences AG
7 Dept. Microbiology and Cell Science, University of Florida
8 Ginkgo Bioworks [Boston, MA, États-Unis]
9 UFGI - University of Florida Genetics Institute
10 School of Molecular Sciences, The University of Western Australia, Perth 6009, Australia
11 Chair of Technical Biochemistry, Technical Université of Dresden
12 School of Chemical Sciences [Auckland]
13 Biosciences Institute, Faculty of Medical Sciences [Newcastle]
14 Sutro Biopharma, South San Francisco
15 Bogor Agricultural University - IPB (INDONESIA)
16 Goethe University Frankfurt
17 LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG)
18 Senckenberg Society for Nature Research
19 Department of Chemistry [University of Warwick]
20 WISB - Warwick Integrative Synthetic Biology Centre
21 Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
22 Collaborative Research institute for Innovative Microbiology, University of Tokyo
23 Translational Genome Mining for Natural Products, University of Tübingen
24 Universität des Saarlandes [Saarbrücken] = Saarland University [Saarbrücken]
25 HZI - Helmholtz Centre for Infection Research
26 UPCité - Université Paris Cité
27 Generare Bioscience [Paris]
28 Rothamsted Research - Department of Soil Science, Harpenden, Royaume Uni
29 computational biology lab, National Agri-food and Biomanufacturing Institute, Punjab
30 Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad
31 UNBC - University of Northern British Columbia [Prince George]
32 Department of Biochemistry and Metabolism, Department of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, United Kingdom
33 Latvian Institute of Organic Synthesis [Riga, Lituania]
34 Department of Pharmaceutical Sciences, Oregon State University
35 Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara
36 Department of Environmental Microbiology, Swiss Federal Institute of Aquatic Science and Technology
37 Plant-Microbe Interactions, Institute of Environmental Biologyutrecht
38 Faculty of Environment, Science and Economy, University of Exeter
39 Department of Pharmaceutical Sciences, University of Basel
40 State Key Laboratory of Microbial Metabolism
41 Department of Biochemistry, University of Johannesburg
42 Omnia Nutriology, Sandton
43 Department of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University
44 Center for Advanced Marine Core Research
45 Department of pharmacology and toxicology, University of Utah
46 Industrial Genomics Laboratory, FEMSA, México
47 Purdue University [West Lafayette]
48 Institute of Chemistry, UNICAMP
49 Department of Applied Sciences, University of Technology, Baghdad
50 School of Life Sciences [Warwick]
51 Department of Food and Animal Sciences, Tennessee State University
52 SWANSEA UNIVERSITY DEPARTMENT OF BIOSCIENCES SWANSEA GBR
53 Escuela Nacional de Estudios Superiores Unidad Léon, Mexico
54 Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
55 IBL - Institute Biology Leiden
56 Center for Marine Biotechnology and Biomedicine
57 IPN - Instituto Politecnico Nacional [Mexico]
58 Department of Chemistry, University of Manitoba
59 Department of Chemistry, University of Illinois Urbana-Champaign
60 Carl R. Woese Institute of Genomic Biology
61 Institute of Pharmaceutical Biology, University of Bonn
62 Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine
63 Institute of Pharmaceutical Biology and Biotechnology, University of Marburg
64 Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico
65 UNMSM - Universidad Nacional Mayor de San Marcos
66 UFRJ - Universidade Federal do Rio de Janeiro [Brasil] = Federal University of Rio de Janeiro [Brazil] = Université fédérale de Rio de Janeiro [Brésil]
67 Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro
68 HU Berlin - Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin
69 Universität Greifswald - University of Greifswald
70 Department of Crop Protection, Instituto de Hortofructicultura Subtropical y Mediterránea, Málaga
71 Department of Microbial Ecology, NIOO-KNAW
72 School of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Leeds
73 Centro Interdisciplinar de Química e Bioloxía, Universidade de Coruña
74 Centre of Biological Engineering, University of Minho
75 Universidad de Málaga [Málaga] = University of Málaga [Málaga]
76 CIMAR - Interdisciplinary Center of Marine and Environmental Research
77 Institute of Microbiology, Technical University of Braunschweig
78 ZMBP - Zentrum für Molekularbiologie der Pflanzen
79 Yeungnam University [South Korea]
80 Research Institute of Cell Culture, Yeungnam University
81 College of Pharmacy and Drug Information Research Institute, Sookmyung Women’s University
82 Fungal Natural Products, Westerdijk Fungal Biodiversity Institute
83 Manchester Institute of Biotechnology
84 Innovative Genomics Institute
85 EPS - Department of Earth and Planetary Science [UC Berkeley]
86 BIOGER - BIOlogie et GEstion des Risques en agriculture
87 IOCB / CAS - Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
88 SZN - Stazione Zoologica Anton Dohrn
89 Department of Biosciences Engineering, University of Antwerp
90 US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA
91 Biochemistry of Microorganisms, Faculty of Life Sciences: Food, Nutrition, and Health, University of Bayreuth, Kulmbach
92 SIB - Swiss Institute of Bioinformatics [Genève]
93 Department of Applied Chemistry and Microbiology [Helsinki]
94 Research Center for Food Technology and Processing, National Research and Innovation Agency, Indonesia
95 BRIN - National Research and Innovation Agency
96 JCVI - J. Craig Venter Institute [La Jolla, USA]
97 NAICONS Srl, viale Ortles 22/4, Milan
98 Department of Chemistry, University of Parma
99 Leibniz Universität Hannover=Leibniz University Hannover
100 VIB-KU Leuven Center for Microbiology [Leuven, Belgium]
101 Department of Biology, Laboratory for Biomolecular Discovery & Engineering, KU Leuven
102 BIOSYST - Department of Biosystems
103 Leibniz-Institut Deutsche Sammlung von Mikroorganismen und Zelllkulturen GmBH - DSMZ (GERMANY)
104 UNAM - Instituto de Matematicas
105 Carnegie Institution for Science
106 Interdepartmental Program in Chemical Biology, University of Michigan
107 Life Sciences Institute [Ann Arbor, MI, USA]
108 University of Groningen [Groningen]
109 Department of Chemistry, The University of Hong Kong
110 Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute)
111 Institute of Infectious Disease Research, McMaster University, Ontario
112 McMaster University Hamilton - Department of Biology
113 SINTEF Industry
114 Microbiology Group, Wageningen University & Research
115 Corteva agriscience
116 Natural Products Research Institute, College of Pharmacy, Seoul National University
117 Center for Cancer Research, National Cancer Institute, Maryland
118 VTT - VTT Technical Research Centre of Finland
119 DCB - Department of Chemistry and Biochemistry, Florida State University, Chieftain Way, Tallahassee, Florida, USA
120 Department of Applied Biology, College of Agricultural and Life Sciences, Chonnam National University, Gwangju
121 Department of Pharmacology, College of Medicine, Dongguk University
122 College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University
123 Department of Biological Sciences, KAIST, Daejeon
124 Department of Paleobiotechnology, Hans Knöll Institute, Jena
125 DTU Bioengineering
126 Department of Chemical and Biomolecular Engineering, University of Delaware
127 DZIF - German Center for Infection Research - partner site Hannover-Braunschweig
128 LUMC - Leiden University Medical Center
129 Endogenomiks, Querétaro, Mexico
130 U-MaMi Centre of Excellence, Antwerp
131 Integrative Biology Research Unit, The Institute of Obesity Research, México
132 School of innovation and Sustainability,De La Salle University, Laguna
133 Department of Chemistry, De La Salle University, Manila
134 University of Strathclyde [Glasgow]
135 Department of Biotechnology and Biomedicine
136 Technical University of Braunschweig, Institute of Microbiology
137 The Ferrier Research Institute
138 Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
139 Department of Biology, Faculty of Sciences, Utrecht University
140 Department of Biological and Chemical Engineering, Aarhus University
141 University of Turku
142 Freie Universität Berlin
143 Ivan Franko National University of Lviv
144 German-Ukrainian Core of Excellence in Natural Products Research, Lviv
145 EGSB - Environmental Genomics and Systems Biology Division [LBNL Berkeley]
146 CIPRONA - Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica
147 Cenibiot - Centro Nacional de Innovaciones Biotecnologicas
148 INIFAR - Instituto de Investigaciones Farmacéuticas, Universidad de Costa Rica
149 Doherty Institute, University of Melbourne
150 Institute of Microbiology [Zurich]
151 Davis Department of Plant Pathology
152 Department of Chemistry [Aarhus]
153 IMSB - Institute for Molecular Systems Biology [ETH Zurich]
154 Laboratorio de Microbiologia Molecular y Biotecnologia Ambiantal, Centro de Biotecnologia DAL, Universidad Tecnica Federico Santa Maria, Valparaiso
155 Department of Chemistry and BioDiscovery Institute, University of North Texas
156 HZI - Helmholtz Center for Infection Research [Braunschweig, Germany]
157 RECETOX / MUNI - Research Centre for Toxic Compounds in the Environment [Brno]
158 School of Biological Sciences [Bristol]
159 School of Chemistry, University of Bristol
160 HiLIFE - Helsinki Institute of Life Science
161 Department of Chemistry, University of Zurich
162 Department of Biology, University of Padova
163 Botanical Garden, University of Padova
164 Department of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University
165 DZIF - German Center for Infectious Research - partner site Tübingen [Tübingen, Allemagne]
166 Groupe De Sangosse
167 LRSV - Laboratoire de Recherche en Sciences Végétales
168 Department of Biology, Laboratory of Biomolecular Discovery & Engineering, KU Leuven
169 IMBM - Institute for Microbial Biotechnology and Metagenomics [Cape Town, South Africa]
170 JIC - Department of Molecular Microbiology John Innes Centre
171 Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford
172 School of Applied Sciences, University of the West of England, Bristol
173 Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada
174 Natural Products Discovery Center, The Herbert Wertheim, Florida
175 Synthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering, Korea University, Seoul
176 Institute of Plant and Food Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China
177 College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals
178 Institute of Chemical, Environmental and Biological Engineering
179 [SFU.ca] - Department of Chemistry [Simon Fraser University]
Kai Blin
- Fonction : co premier-auteur
- PersonId : 1344827
- ORCID : 0000-0003-3764-6051
Jorge Navarro
- Fonction : Auteur
- PersonId : 1477474
- ORCID : 0000-0003-2992-1607
Catarina Loureiro
- Fonction : Auteur
- PersonId : 1477475
- ORCID : 0000-0002-6258-2080
Justin J van der Hooft
- Fonction : Auteur
- PersonId : 1250516
- ORCID : 0000-0002-9340-5511
Roger G Linington
- Fonction : Auteur
- PersonId : 1344851
- ORCID : 0000-0003-1818-4971
Tilmann Weber
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- Fonction : Auteur correspondant
- PersonId : 779661
- ORCID : 0000-0002-8260-5120
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Marnix H Medema
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- PersonId : 1092091
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Résumé
Abstract Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.
Domaines
Sciences du Vivant [q-bio]| Origine | Fichiers produits par l'(les) auteur(s) |
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