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Isolation, caracterization and use of a Vibrio spp. collection in order to develop a phage therapy product for shrimp aquaculture.

Abstract : Human population is going to reach 9.7 billion by 2050 according to UN. This growth needs to be followed by an increase in food production, of which aquaculture is foreseen to take the biggest part. Aquaculture industry’s growth is however threatened by the mandatory diminution of antibiotics use, which are used to treat bacterial diseases such as vibriosis. Bacteriophages (phages) are virus infecting bacteria. They are among the most promising antibiotic alternatives for aquaculture. This thesis is part of a Project that aims at gathering phages able to treat vibriosis in shrimp farms. The first step to achieve this was to build and caracterize a Vibrio spp. strain collection, which was then used to obtain phages. A 234 Vibrio spp. Strain colection was therefore built. The study of the genome of 15 strains allowed the discovery of 4 new species. And 7 phage variants were isolated and caracterized, by various techniques including genome analysis. The workflow developped in this study, the bacterial strain collection and the recommandation for phage isolation given in this document are a first step towards the developpment of a phage-based product for Mixscience company.
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https://hal.inrae.fr/tel-03109829
Contributor : Anne Giboulot <>
Submitted on : Thursday, January 14, 2021 - 9:13:41 AM
Last modification on : Friday, February 5, 2021 - 3:57:46 AM

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  • HAL Id : tel-03109829, version 1

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Antoine Culot. Isolation, caracterization and use of a Vibrio spp. collection in order to develop a phage therapy product for shrimp aquaculture.. Microbiology and Parasitology. Agrocampus Ouest COMUE bRETAGNE lOIRE, 2020. English. ⟨tel-03109829⟩

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