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Application de la classification biopharmaceutique des médicaments au développement de compléments nutritionnels et évaluation de l’impact de la qualité des ingrédients sur la biodisponibilité

Abstract : This research work is part of the CALC (Targeted Release Food Supplement) project, which focuses on the application of the biopharmaceutical classification of drugs to the development of nutritional supplements. In line with the development of medicines, applied to the pharmaceutical industry, reflections are emerging at the level of food supplements, both from the authorities and from the players in the sector (industrialists and researchers). These major points of reflection concern i) the quality of raw material sources, ii) their physical-chemical characteristics and functional properties, iii) the impact of the administration matrix on the "bioaccessibility" of the active ingredients and iv) the bioavailability and interchangeability of the food supplements available on the market. These lines of research aim to improve the quality and safety of products to ensure optimal efficacy and reduced safety for the consumer. Recognising that the dissolution and gastrointestinal permeability of a chemical molecule are the fundamental parameters that control its rate of absorption and amount absorbed, the biopharmaceutical classification scheme for drugs is adopted by the EMA and FDA in similar texts. The aim of the work was to propose a classification for nutritional supplements that would improve the quality and bioavailability of the ingredients they contain. The work consisted of i) studying the physicochemical and biopharmaceutical properties of different nutritional ingredients including caffeine, glucosamine, resveratrol and curcumin ii) assessing the impact of physicochemical and biopharmaceutical properties on the interchangeability of products and their bioavailability iii) proposing an original classification of nutritional ingredients that would allow the elaboration of a reasoned development strategy.
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https://hal.inrae.fr/tel-03250231
Contributor : Stéphanie Dutilloy <>
Submitted on : Friday, June 4, 2021 - 3:43:04 PM
Last modification on : Saturday, June 5, 2021 - 3:41:12 AM

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  • HAL Id : tel-03250231, version 1

Citation

Ali Begag. Application de la classification biopharmaceutique des médicaments au développement de compléments nutritionnels et évaluation de l’impact de la qualité des ingrédients sur la biodisponibilité. Sciences du Vivant [q-bio]. Université Clermont Auvergne, 2020. Français. ⟨tel-03250231⟩

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