Bacteria are frequently exposed to nutrient limiting conditions as well as many environmental stresses. The ability of the bacterial cell to survive such variations depends on its ability to sense these changes and respond to them through perfectly coordinated regulatory networks. These temporal phenomena with many actors and dynamic aspects constitute complex biological questions, which have always fascinated me. During my research projects, I have studied the role of transcriptional regulators involved in metal ion homeostasis and in the response to oxidative stress in the soil bacterium Bacillus subtilis. More recently, I reoriented my projects on the study of the strict anaerobic commensal bacteria Faecalibactrium, which play a major role in digestive health within the human gut microbiota. I am particularly interested in the diversity of MAM (Microbial Anti-inflammatory Molecule) proteins and the oxidative stress response of different strains whose abundance is altered in an inflammatory intestinal context. I am also leading a project at the interface between bioinformatics / microbiology on the prediction and validation of small proteins synthesized by Faecalibactrium and which would play a role in the maintenance of the microbiota-host holobiont.