Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Ophthalmology: Journal of The American Academy of Ophthalmology Year : 2018

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Monique Breteler , Matthias Mauschitz , Pieter W.M. Bonnemaijer , Kersten Diers , Franziska Rauscher , Tobias Elze , Christoph Engel , Markus Loeffler , Johanna Maria Colijn , M. Arfan Ikram , Johannes Vingerling , Katie Williams , Christopher Hammond , Catherine Creuzot-Garcher (1, 2) , Alain M. Bron (1, 2) , Rufino Silva , Sandrina Nunes , Cécile Delcourt (3) , Audrey Cougnard-Grégoire (3) , Frank G. Holz , Caroline C.W. Klaver , Monique M.B. Breteler , Robert Finger , Niyazi Acar , Eleftherios Anastosopoulos , Augusto Azuara-Blanco , Tos Berendschot , Arthur Bergen , Geir Bertelsen , Christine Binquet , Alan Bird , Martin Bobak , Morten Bøgelund Larsen , Camiel Boon , Rupert Bourne , Lionel Brétillon , Rebecca Broe , Gabrielle Buitendijk , Maria Luz Cachulo , Vittorio Capuano , Isabelle Carrière , Usha Chakravarthy , Michelle Chan , Petrus Chang , Johanna Colijn , Angela Cree , Phillippa Cumberland , José Cunha-Vaz , Vincent Daien (4, 5) , Eiko de Jong , Gabor Deak , Marie-Noëlle Delyfer , Anneke Den Hollander , Martha Dietzel , Maja Gran Erke , Pedro Faria , Claudia Farinha , Sascha Fauser , Astrid Fletcher , Paul Foster , Panayiota Founti , Theo Gorgels , Jakob Grauslund , Franz Grus , Hans-Werner Hense , Manuel Hermann , René Hoehn , Ruth Hogg , Carel Hoyng , Nomdo Jansonius , Sarah Janssen , Eveline Kersten , Anthony Khawaja , Caroline Klaver , Jean-François Korobelnik , Julia Lamparter , Mélanie Le Goff , Yara Lechanteur , Terho Lehtimäki , Irene Leung , Andrew Lotery , Magda Meester , Bénédicte Merle , Verena Meyer zu Westrup , Edoardo Midena , Stefania Miotto , Alireza Mirshahi , Sadek Mohan-Saïd , Michael Mueller , Alyson Muldrew , Joaquim Murta , Stefan Nickels , Christopher Owen , Tunde Peto , Norbert Pfeiffer , Stefano Piermarocchi , Elena Prokofyeva , Jugnoo Rahi , Olli Raitakari , Luisa Ribeiro , Marie-Bénédicte Rougier , Alicja Rudnicka , José Sahel , Aggeliki Salonikiou , Clarisa Sanchez , Steffen Schmitz-Valckenberg , Alexander Schuster , Cédric Schweitzer , Tatiana Segato , Jasmin Shehata , Giuliana Silvestri , Christian Simader , Eric Souied , Martynas Speckauskas , Henriët Springelkamp , Robyn J. Tapp , Fotis Topouzis , Elisa van Leeuwen , Virginie Verhoeven , Timo Verzijden , Therese von Hanno , Peter Wiedemann , Christian Wolfram , Jennifer Yip , Jennyfer Zerbib
Monique Breteler
  • Function : Author
Matthias Mauschitz
  • Function : Author
Pieter W.M. Bonnemaijer
  • Function : Author
Kersten Diers
  • Function : Author
Franziska Rauscher
  • Function : Author
Tobias Elze
  • Function : Author
Christoph Engel
  • Function : Author
Markus Loeffler
  • Function : Author
Johanna Maria Colijn
  • Function : Author
M. Arfan Ikram
  • Function : Author
Johannes Vingerling
  • Function : Author
Katie Williams
  • Function : Author
Christopher Hammond
  • Function : Author
Rufino Silva
  • Function : Author
Sandrina Nunes
  • Function : Author
  • PersonId : 889531
Cécile Delcourt
Frank G. Holz
  • Function : Author
Caroline C.W. Klaver
  • Function : Author
Monique M.B. Breteler
  • Function : Author
Robert Finger
Niyazi Acar
Eleftherios Anastosopoulos
  • Function : Contributor
Augusto Azuara-Blanco
  • Function : Contributor
Tos Berendschot
  • Function : Contributor
Arthur Bergen
Geir Bertelsen
  • Function : Contributor
Christine Binquet
Alan Bird
  • Function : Contributor
Martin Bobak
  • Function : Contributor
Morten Bøgelund Larsen
  • Function : Contributor
Camiel Boon
  • Function : Contributor
Rupert Bourne
  • Function : Contributor
Lionel Brétillon
Rebecca Broe
  • Function : Contributor
Gabrielle Buitendijk
  • Function : Contributor
Maria Luz Cachulo
  • Function : Contributor
Vittorio Capuano
  • Function : Contributor
Isabelle Carrière
  • Function : Contributor
  • PersonId : 836149
Usha Chakravarthy
  • Function : Contributor
Michelle Chan
  • Function : Contributor
Petrus Chang
  • Function : Contributor
Johanna Colijn
  • Function : Contributor
Angela Cree
  • Function : Contributor
Phillippa Cumberland
  • Function : Contributor
José Cunha-Vaz
  • Function : Contributor
  • PersonId : 889535
Eiko de Jong
  • Function : Contributor
Gabor Deak
  • Function : Contributor
Marie-Noëlle Delyfer
  • Function : Contributor
Anneke Den Hollander
  • Function : Contributor
Martha Dietzel
  • Function : Contributor
Maja Gran Erke
  • Function : Contributor
Pedro Faria
  • Function : Contributor
Claudia Farinha
  • Function : Contributor
Sascha Fauser
  • Function : Contributor
Astrid Fletcher
  • Function : Contributor
Paul Foster
  • Function : Contributor
Panayiota Founti
  • Function : Contributor
  • PersonId : 869381
Theo Gorgels
  • Function : Contributor
Jakob Grauslund
  • Function : Contributor
Franz Grus
  • Function : Contributor
Hans-Werner Hense
  • Function : Contributor
Manuel Hermann
  • Function : Contributor
René Hoehn
  • Function : Contributor
Ruth Hogg
  • Function : Contributor
Carel Hoyng
  • Function : Contributor
Nomdo Jansonius
  • Function : Contributor
Sarah Janssen
Eveline Kersten
  • Function : Contributor
Anthony Khawaja
  • Function : Contributor
Caroline Klaver
  • Function : Contributor
Jean-François Korobelnik
Julia Lamparter
  • Function : Contributor
Mélanie Le Goff
  • Function : Contributor
Yara Lechanteur
  • Function : Contributor
Terho Lehtimäki
  • Function : Contributor
Irene Leung
  • Function : Contributor
Andrew Lotery
  • Function : Contributor
Magda Meester
  • Function : Contributor
Bénédicte Merle
  • Function : Contributor
Verena Meyer zu Westrup
  • Function : Contributor
Edoardo Midena
  • Function : Contributor
  • PersonId : 892383
Stefania Miotto
  • Function : Contributor
Alireza Mirshahi
  • Function : Contributor
Sadek Mohan-Saïd
  • Function : Contributor
Michael Mueller
  • Function : Contributor
Alyson Muldrew
  • Function : Contributor
Joaquim Murta
  • Function : Contributor
Stefan Nickels
  • Function : Contributor
Christopher Owen
Tunde Peto
  • Function : Contributor
Norbert Pfeiffer
  • Function : Contributor
Stefano Piermarocchi
  • Function : Contributor
Elena Prokofyeva
  • Function : Contributor
Jugnoo Rahi
  • Function : Contributor
Olli Raitakari
  • Function : Contributor
Luisa Ribeiro
  • Function : Contributor
Marie-Bénédicte Rougier
  • Function : Author
  • PersonId : 1028455
Alicja Rudnicka
  • Function : Contributor
José Sahel
  • Function : Contributor
Aggeliki Salonikiou
  • Function : Contributor
Clarisa Sanchez
  • Function : Contributor
Steffen Schmitz-Valckenberg
  • Function : Contributor
Alexander Schuster
  • Function : Contributor
Cédric Schweitzer
  • Function : Contributor
  • PersonId : 780906
  • IdRef : 133631583
Tatiana Segato
  • Function : Contributor
Jasmin Shehata
  • Function : Contributor
Giuliana Silvestri
  • Function : Contributor
  • PersonId : 900626
Christian Simader
  • Function : Contributor
  • PersonId : 874672
Eric Souied
  • Function : Contributor
Martynas Speckauskas
  • Function : Contributor
Henriët Springelkamp
  • Function : Contributor
Robyn J. Tapp
  • Function : Contributor
Fotis Topouzis
  • Function : Contributor
Elisa van Leeuwen
  • Function : Contributor
Virginie Verhoeven
  • Function : Contributor
Timo Verzijden
  • Function : Contributor
Therese von Hanno
  • Function : Contributor
Peter Wiedemann
  • Function : Contributor
Christian Wolfram
  • Function : Contributor
Jennifer Yip
  • Function : Contributor
Jennyfer Zerbib
  • Function : Contributor

Abstract

PURPOSE:To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population.DESIGN:Cross-sectional meta-analysis.PARTICIPANTS:A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3-82.1±4.2 years) of the European Eye Epidemiology (E3) consortium.METHODS:We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis.MAIN OUTCOME MEASURES:Determinants of pRNFLT.RESULTS:Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = -0.38 μm/year; 95% confidence interval [CI], -0.57 to -0.18), higher intraocular pressure (IOP) (β = -0.36 μm/mmHg; 95% CI, -0.56 to -0.15), visual impairment (β = -5.50 μm; 95% CI, -9.37 to -1.64), and history of systemic hypertension (β = -0.54 μm; 95% CI, -1.01 to -0.07) and stroke (β = -1.94 μm; 95% CI, -3.17 to -0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = -3.11 μm; 95% CI, -6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19-1.59) and smoking (β = 1.53 μm; 95% CI, 1.00-2.06 for current smokers compared with never-smokers).CONCLUSIONS:In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.
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hal-02341481 , version 1 (17-03-2024)

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Monique Breteler, Matthias Mauschitz, Pieter W.M. Bonnemaijer, Kersten Diers, Franziska Rauscher, et al.. Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population. Ophthalmology: Journal of The American Academy of Ophthalmology, 2018, 125 (10), pp.1526-1536. ⟨10.1016/j.ophtha.2018.03.026⟩. ⟨hal-02341481⟩
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