Hippocampal CB1 receptors control incidental associations - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Neuron Year : 2018

Hippocampal CB1 receptors control incidental associations

Xavier Fioramonti

Abstract

By priming brain circuits, associations between low-salience stimuli often guide future behavioral choices through a process known as mediated or inferred learning. However, the precise neurobiological mechanisms of these incidental associations are largely unknown. Using sensory preconditioning procedures, we show that type 1 cannabinoid receptors (CB1R) in hippocampal GABAergic neurons are necessary and sufficient for mediated but not direct learning. Deletion and re-expression of CB1R in hippocampal GABAergic neurons abolishes and rescues mediated learning, respectively. Interestingly, paired presentations of low-salience sensory cues induce a specific protein synthesis-dependent enhancement of hippocampal CB1R expression and facilitate long-term synaptic plasticity at inhibitory synapses. CB1R blockade or chemogenetic manipulations of hippocampal GABAergic neurons upon preconditioning affect incidental associations, as revealed by impaired mediated learning. Thus, CB1R-dependent control of inhibitory hippocampal neurotransmission mediates incidental associations, allowing future associative inference, a fundamental process for everyday life, which is altered in major neuropsychiatric diseases.
Fichier principal
Vignette du fichier
MAGENDIE_Neuron_2018_BusquetsGarcia.pdf (12.39 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-02626385 , version 1 (06-02-2024)

Identifiers

Cite

Arnau Busquets-Garcia, José F. Oliveira da Cruz, Geoffrey Terral, Antonio C. Pagano Zottola, Edgar Soria-Gomez, et al.. Hippocampal CB1 receptors control incidental associations. Neuron, 2018, 99 (6), pp.1247-1259. ⟨10.1016/j.neuron.2018.08.014⟩. ⟨hal-02626385⟩
20 View
3 Download

Altmetric

Share

Gmail Facebook X LinkedIn More