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Aggregation of omic data and secretome prediction enable the discovery of candidate plasma biomarkers for beef tenderness

Abstract : Beef quality is a complex phenotype that can be evaluated only after animal slaughtering. Previous research has investigated the potential of genetic markers or muscle-derived proteins to assess beef tenderness. Thus, the use of low-invasive biomarkers in living animals is an issue for the beef sector. We hypothesized that publicly available data may help us discovering candidate plasma biomarkers. Thanks to a review of the literature, we built a corpus of articles on beef tenderness. Following data collection, aggregation, and computational reconstruction of the muscle secretome, the putative plasma proteins were searched by comparison with a bovine plasma proteome atlas and submitted to mining of biological information. Of the 44 publications included in the study, 469 unique gene names were extracted for aggregation. Seventy-one proteins putatively released in the plasma were revealed. Among them 13 proteins were predicted to be secreted in plasma, 44 proteins as hypothetically secreted in plasma, and 14 additional candidate proteins were detected thanks to network analysis. Among these 71 proteins, 24 were included in tenderness quantitative trait loci. The in-silico workflow enabled the discovery of candidate plasma biomarkers for beef tenderness from reconstruction of the secretome, to be examined in the cattle plasma proteome.
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https://hal.inrae.fr/hal-02516737
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Submitted on : Tuesday, May 26, 2020 - 10:23:37 PM
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Sabrina Boudon, Joëlle Henry-Berger, Isabelle Cassar-Malek. Aggregation of omic data and secretome prediction enable the discovery of candidate plasma biomarkers for beef tenderness. International Journal of Molecular Sciences, MDPI, 2020, 21 (2), pp.1-33. ⟨10.3390/ijms21020664⟩. ⟨hal-02516737⟩

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