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Vaccination anti-brucellique du bouquetin des Alpes (Capra ibex), une option pour l'assainissement du massif du Bargy ? Résultats d'une première expérimentation visant à comparer le niveau d'innocuité du vaccin REV.1 conjonctival chez le bouquetin des Alpes et la chèvre domestique (C. hircus)

Abstract : Rev.1 is a stable live attenuated vaccine, which has significantly contributed to reduce the incidence of brucellosis due to Brucella melitensis in many countries, provided a sufficient coverage of sheep and goat populations was achieved. As regards the control of the brucellosis outbreak in Alpine ibex, an experiment to compare the safety of conjunctival Rev.1 vaccination between domestic goats and Alpine ibex was undertaken in spring 2017. Twenty-four adult animals were included in the study, divided into two batches of 6 males and two batches of 6 non-pregnant females of each species, for a period of 45 or 90 days. The Rev.1 vaccine resulted in a humoral response in all vaccinated animals, with a higher intensity in ibex compared to goats, regardless of age and sex. The risk resulted in the Rev.1 transmission from vaccinated ibex to one control animal. Despite what the genetic proximity between goat and ibex might suggest, the distribution of Rev.1 in organs and the risk of urogenital excretion were much more marked in ibex than in goats, all ages and sexes combined. These results highlight a reduced ability of Alpine ibex to contain the spread, multiplication and excretion of Rev.1 vaccine, suggesting a risk of spread of the vaccine strain in the ibex population. In nature, the uncontrolled diffusion of the vaccine strain may impair surveillance and management of this outbreak, inducing seroconversions of animals, without difference between animals infected from wild and vaccine strains.
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https://hal.inrae.fr/hal-02620515
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Submitted on : Monday, May 25, 2020 - 11:15:04 PM
Last modification on : Tuesday, November 16, 2021 - 5:15:12 AM

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  • HAL Id : hal-02620515, version 1
  • PRODINRA : 459039

Citation

Claire Ponsart, Bruno Garin-Bastuji, Mickaël Riou, Yann Locatelli, Alain Fadeau, et al.. Vaccination anti-brucellique du bouquetin des Alpes (Capra ibex), une option pour l'assainissement du massif du Bargy ? Résultats d'une première expérimentation visant à comparer le niveau d'innocuité du vaccin REV.1 conjonctival chez le bouquetin des Alpes et la chèvre domestique (C. hircus). Epidémiologie et Santé Animale, Association pour l'Etude de l'Epidémiologie des Maladies Animales (AEEMA), 2018, 74, pp.25-42. ⟨hal-02620515⟩

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