 |
Article dans une revue
Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits
Abstract : Airborne pollution is a rising concern in urban areas. Epidemiological studies in humans and animal experiments using rodent models indicate that gestational exposure to airborne pollution, in particular diesel engine exhaust (DE), reduces birth weight, but effects depend on exposure duration, gestational window and nanoparticle (NP) concentration. Our aim was to evaluate the effects of gestational exposure to diluted DE on feto-placental development in a rabbit model. Pregnant females were exposed to diluted (1 mg/m(3)), filtered DE (NP diameter ≈ 69 nm) or clean air (controls) for 2 h/day, 5 days/week by nose-only exposure (total exposure: 20 days in a 31-day gestation). DE exposure induced early signs of growth retardation at mid gestation with decreased head length (p = 0.04) and umbilical pulse (p = 0.018). Near term, fetal head length (p = 0.029) and plasma insulin and IGF1 concentrations (p = 0.05 and p = 0.019) were reduced. Placental function was also affected, with reduced placental efficiency (fetal/placental weight) (p = 0.049), decreased placental blood flow (p = 0.009) and fetal vessel volume (p = 0.002). Non-aggregated and "fingerprint" NP were observed at various locations, in maternal blood space, in trophoblastic cells and in the fetal blood, demonstrating transplacental transfer. Adult female offspring were bred with control males. Although fetoplacental biometry was not affected near term, second generation fetal metabolism was modified by grand-dam exposure with decreased plasma cholesterol (p = 0.008) and increased triglyceride concentrations (p = 0.015). Repeated daily gestational exposure to DE at levels close to urban pollution can affect feto-placental development in the first and second generation.
Littérature citée [50 références]
https://hal.inrae.fr/hal-02637441
Déposant : Migration Prodinra <>
Soumis le : mercredi 27 mai 2020 - 23:03:28
Dernière modification le : mardi 17 novembre 2020 - 18:24:03
Déposant : Migration Prodinra <>
Soumis le : mercredi 27 mai 2020 - 23:03:28
Dernière modification le : mardi 17 novembre 2020 - 18:24:03
Fichiers
2016_Valentino_Particle and Fi...
Fichiers éditeurs autorisés sur une archive ouverte
- 2017_Best paper Particle and Fibre Toxicology_2.pdf Fichiers produits par l'(les) auteur(s)
Licence
Distributed under a Creative Commons Paternité - Partage selon les Conditions Initiales 4.0 International License
Données personnelles 
Mentions légales 