Climate change impacts grapevine and wine and questions winegrowers about their strategies and agronomical practices. From a research point of view, climate change over the past decades has mainly concerned the increase in temperatures. It has resulted in advanced phenological stages and harvest date, accompanied by an increase in grapes sugar content and a decrease in their acidity. The perception of climate change by the growers has been studied for the last 15 years. Most of them have also noted changes in climatic conditions and vine behavior. Continued climate change raises many questions, ranging from the future of “terroirs” and wines typicality up to the very maintenance of an economic activity in some wine-growing regions. Grapevine is a perennial plant grown in very different environments; therefore adaptation strategies must be considered in each region from the short term to the long term and declined from the parcel to the territory. They are both rich in existing experiences and complex in their implementation due to the diversity of environmental and human factors to integrate. They offer a favorable basis for feeding the co-construction of agricultural knowledge between winegrowers, technicians and researchers.