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La myostatine : un régulateur négatif de la masse musculaire chez les vertébrés

Abstract : In livestock the double-muscled phenotype is well known and has been selected in certain breeds, in order to increase carcass yield . Even though the chromosomal location of the gene responsible for the double-muscled phenotype in cattle has been known for a long time, the gene was identified more recently with studies in mice. In fact, mutations present in the growth factor myostatin gene cause the doublemuscled phenotype. Myostatin is a negative regulator of muscle mass and plays a key role in muscle homeostasis. Myostatin also appears to be involved in the control of adipogenesis and osteogenesis. This review provides an update on the current state of the knowledge of myostatin and on the rational use of such knowledge in agronomy for meat production.
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Ilham Chelh, Julie Rodriguez, Anne Bonnieu, Isabelle Cassar-Malek, Patrick Cottin, et al.. La myostatine : un régulateur négatif de la masse musculaire chez les vertébrés. INRA Productions Animales, Paris: INRA, 2009, 22 (5), pp.397-408. ⟨hal-02664023⟩

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