Skip to Main content Skip to Navigation
Journal articles

Fecal microbiota transplant from human to mice gives insights into the role of the gut microbiota in non-alcoholic fatty liver disease (NAFLD)

Abstract : Non-alcoholic fatty liver diseases (NAFLD) are associated with changes in the composition and metabolic activities of the gut microbiota. However, the causal role played by the gut microbiota in individual susceptibility to NAFLD and particularly at its early stage is still unclear. In this context, we transplanted the microbiota from a patient with fatty liver (NAFL) and from a healthy individual to two groups of mice. We first showed that the microbiota composition in recipient mice resembled the microbiota composition of their respective human donor. Following administration of a high-fructose, high-fat diet, mice that received the human NAFL microbiota (NAFLR) gained more weight and had a higher liver triglycerides level and higher plasma LDL cholesterol than mice that received the human healthy microbiota (HR). Metabolomic analyses revealed that it was associated with lower and higher plasma levels of glycine and 3-Indolepropionic acid in NAFLR mice, respectively. Moreover, several bacterial genera and OTUs were identified as differently represented in the NAFLR and HR microbiota and therefore potentially responsible for the different phenotypes observed. Altogether, our results confirm that the gut bacteria play a role in obesity and steatosis development and that targeting the gut microbiota may be a preventive or therapeutic strategy in NAFLD management.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-03123187
Contributor : Philippe Gérard <>
Submitted on : Wednesday, January 27, 2021 - 3:45:13 PM
Last modification on : Tuesday, June 15, 2021 - 2:57:34 PM

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Links full text

Identifiers

Citation

Sebastian Burz, Magali Monnoye, Catherine Philippe, William Farin, Vlad Ratziu, et al.. Fecal microbiota transplant from human to mice gives insights into the role of the gut microbiota in non-alcoholic fatty liver disease (NAFLD). Microorganisms, MDPI, 2021, 9 (1), pp.199. ⟨10.3390/microorganisms9010199⟩. ⟨hal-03123187⟩

Share

Metrics

Record views

39