Ph2 encodes the mismatch repair protein MSH7-3D that inhibits wheat homoeologous recombination - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Nature Communications Year : 2021

Ph2 encodes the mismatch repair protein MSH7-3D that inhibits wheat homoeologous recombination

Abstract

Meiotic recombination is a critical process for plant breeding, as it creates novel allele combinations that can be exploited for crop improvement. In wheat, a complex allohexaploid that has a diploid-like behaviour, meiotic recombination between homoeologous or alien chromosomes is suppressed through the action of several loci. Here, we report positional cloning of Pairing homoeologous 2 (Ph2) and functional validation of the wheat DNA mismatch repair protein MSH7-3D as a key inhibitor of homoeologous recombination, thus solving a half-century-old question. Similar to ph2 mutant phenotype, we show that mutating MSH7-3D induces a substantial increase in homoeologous recombination (up to 5.5 fold) in wheat-wild relative hybrids, which is also associated with a reduction in homologous recombination. These data reveal a role for MSH7-3D in meiotic stabilisation of allopolyploidy and provides an opportunity to improve wheat's genetic diversity through alien gene introgression, a major bottleneck facing crop improvement.
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hal-03135950 , version 1 (28-05-2021)

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Heïdi Serra, Radim Svačina, Ute Baumann, Ryan Whitford, Tim Sutton, et al.. Ph2 encodes the mismatch repair protein MSH7-3D that inhibits wheat homoeologous recombination. Nature Communications, 2021, 12 (1), pp.1-10. ⟨10.1038/s41467-021-21127-1⟩. ⟨hal-03135950⟩
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