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Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Zahari Vinarov 1, 2 Bertil Abrahamsson 3 Per Arturssond 4 Hannah Batchelor 5 Philippe Berben 6 Andreas Bernkop-Schnürch 7 James Butler 8 Jens Ceulemans 9 Nigel Davies 10 Didier Dupont 11 Gøril Eide Flaten 12 Nikoletta Fotaki Fotaki 13 Brendan T. Griffin 14 Vincent Janin 15 Janneke Keemink 9 Filippos Kesisoglou 16 Mirko Koziolek 17 Martin Kuentz 18 Alan Mackie 19 Antonio J. Meléndez-Martínez 20 Mark Mcallister 21 Anette Müllertz 22 Caitriona M. O'Driscoll 14 Neil Parrott 23 Jadwiga Paszkowska 24 Petr Pavek 25 Christopher J.H. Porter 26 Christos Reppas 27 Cordula Stillhart 23 Kiyohiko Sugano 28 Elena Toader 29 Kateřina Valentová 30 Maria Verztoni 27 Saskia N. Dewildt 31 Clive G. Wilson 5 Patrick Augustijns 1
1 Department of Pharmaceutical and Pharmacological Sciences, KU Leuven
KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
2 Department of Chemical and Pharmaceutical Engineering
Medical University of Sofia [Bulgarie]
3 Oral Product Development, Pharmaceutical Technology & Development, Operations
12 Department of Pharmacy
UiT - University of Tromsø
13 Department of Pharmacy and Pharmacology
University of Bath [Bath]
14 School of Pharmacy
UCC - University College Cork
15 Lonza Pharma & Biotech
Lonza AG, Valais Works, CH-3930 Visp, Switzerland
16 Pharmaceutical Sciences, Merck & Co. Inc.
Merck Research laboratories
18 Institute for Pharma Technology
HES-SO - University of Applied Sciences and Arts Northwestern Switzerland
21 Drug Product Design
Pfizer PGRD
22 Department of Pharmacy
KU - University of Copenhagen = Københavns Universitet
25 Faculty of Pharmacy
Charles University Faculty of Medicine and Faculty Hospital in Hradec Kralove
Abstract : Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realmof food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research
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Contributor : Anne Giboulot <>
Submitted on : Thursday, March 4, 2021 - 12:02:54 PM
Last modification on : Friday, March 5, 2021 - 3:30:43 AM


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Zahari Vinarov, Bertil Abrahamsson, Per Arturssond, Hannah Batchelor, Philippe Berben, et al.. Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network. Advanced Drug Delivery Reviews, Elsevier, 2021, 171, pp.289-331. ⟨10.1016/j.addr.2021.02.001⟩. ⟨hal-03159108⟩



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