Extracellular Vesicles and Their Role in Staphylococcus aureus Resistance and Virulence - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Chapitre D'ouvrage Année : 2021

Extracellular Vesicles and Their Role in Staphylococcus aureus Resistance and Virulence

Résumé

Staphylococcus aureus is a pathogen of great importance to clinical and veterinary medicine. Recently, there has been a growing interest in S. aureus extracellular vesicles (EVs) in the pathogenesis of this bacterium. Released by living cells into the extracellular milieu, EVs are membranous structures carrying macromolecules such as proteins, nucleic acids, and metabolites. These structures play several physiological roles and are, among others, considered a mechanism of intercellular communication within S. aureus populations but also in trans kingdom interactions. S. aureus EVs were shown to transport important bacterial survival and virulence factors, such as β-lactamases, toxins, and proteins associated with bacterial adherence to host cells, and to trigger the production of cytokines and promote tissue inflammation. In this chapter, we will review the main studies regarding S. aureus EVs, including their composition and roles in host-pathogen interactions, and the possible applications of EVs for vaccines and therapy development against staphylococcal infections.
Fichier principal
Vignette du fichier
2021_Brenda_Chapter_75145.pdf (861.58 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03163726 , version 1 (09-03-2021)

Licence

Paternité

Identifiants

Citer

Brenda Silva Rosa da Luz, Yves Le Loir, Vasco Azevedo, Eric Guédon. Extracellular Vesicles and Their Role in Staphylococcus aureus Resistance and Virulence. Staphylococcus aureus, IntechOpen, 2021, 978-1-83962-743-9. ⟨10.5772/intechopen.96023⟩. ⟨hal-03163726⟩
113 Consultations
283 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More