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Application in nutrition: mineral binding

Abstract : Minerals are essential to different biological processes in living beings. Likewise, free transition metals such as copper and iron promote the formation of reactive oxygen species (ROSs). However, metal-binding peptides obtained by enzymatic hydrolysis of proteins or synthesized by solid-phase peptide synthesis avoid ROS formation catalyzed by free transition metals. Interactions between metals and mineral-binding peptides (MBPs) are usually studied using spectroscopic techniques, isothermal titration calorimetry, and more recently by surface plasmon resonance and switchSENSE. Through electrospray ionization-mass spectrometry, the changes in the binding affinities can be studied. MBPs can be purified using immobilized metal-ion affinity chromatography, and its process simulation. Various cellular models are used to investigate the health effects of MBPs.
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https://hal.inrae.fr/hal-03267562
Contributor : Anne Giboulot <>
Submitted on : Tuesday, June 22, 2021 - 3:20:08 PM
Last modification on : Friday, September 10, 2021 - 1:04:03 PM

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Sarah El Hajj, Tatiana Sepulveda-Rincon, Cédric Paris, Tristan Giraud, Gizella Csire, et al.. Application in nutrition: mineral binding. Academic Press. Biologically Active Peptides, From Basic Science to Applications for Human Health, Elsevier, 2021, 9780128213896. ⟨10.1016/B978-0-12-821389-6.00016-9⟩. ⟨hal-03267562⟩

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