Effect of the rheological properties of the liquid carrier on the in vitro swallowing of solid oral dosage forms
Résumé
Solid oral dosage forms (SODF) are the most popular oral drug delivery forms, but they can be difficult to swallow, especially for patients suffering from swallowing disorders. This study investigated the dynamics of different combinations of liquid carriers and SODF during the oral phase of swallowing using an in vitro model. The rheological properties of the carriers were characterized using shear and extensional rheometry, and their effect on bolus velocity, bolus shape, post-swallow residues,
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Lavoisier, Shreeram, Jedwab, Ramaioli - JTS 2021.pdf (1.23 Mo)
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