Pasteurella multocida experimental infection 1): resistance and hematological response
Résumé
Pasteurellosis is the first cause of female mortality in rabbit farms. During the RELAPA project (Genomics for the Genetic Resistance of Rabbits to Pasteurellosis), 953 rabbits were inoculated at 6 weeks of age with a pyogenic strain of Pasteurella multocida (Pm) and were monitored during 14 days. Disease response was very variable among animals, with 7% of resistant animals and 11% of highly susceptible rabbits. Blood cell counts were performed at day 14 after inoculation on 574 inoculated and 28 control rabbits. Significant differences in white blood cell, red blood cell, and platelet counts were observed according to the disease resistance score. Susceptible rabbits have a lower red blood cell count, probably due to the hemolytic and hemorrhagic activity of Pm. They also have a higher percentage of monocytes, neutrophils and eosinophils (mainly involved in the innate immune system and inflammatory responses) and, conversely, a lower percentage of lymphocytes (mainly involved in the adaptive immune response) compared to highly resistant and control rabbits. They do not seem able to mount an effective immune response to control the infection.
Domaines
Génétique animale
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