Untargeted peptidomics approach of sheep and goat infant formulas submitted to in vitro digestions - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Poster De Conférence Année : 2022

Untargeted peptidomics approach of sheep and goat infant formulas submitted to in vitro digestions

Résumé

Background: Untargeted peptidomics are well established holistic disciplines enabling researchers to characterize functional characteristics of foods at a molecular level. The aim of this work was to employ a comparative peptidomics approach to identify and measure relative quantities of sheep and goat formula milk peptides after in vitro gastrointestinal digestion. Method: Goat and sheep infant formulas were submitted to dynamic in vitro gastro-intestinal digestions using the DIDGI® system adapted to the newborn digestive conditions. High resolution nanoLC mass spectrometry analysis allowed the comparison of the kinetic of peptides released during digestions. Results and Conclusions: Peptides deriving from osteopontin-1, amylopid A and lactotransferrin, GlyCAM1 were characteristics of sheep and goat formula milk, respectively. Additionally, 280 and 330 peptides were already present in sheep and goat milk before ingestion, indicating that proteolysis events occurred in milk during formula transformation and storage processes. Furthermore, milk peptides were also checked for their unique functional properties, such as anti-hypertensive, immunomodulatory and prebiotic activities. Comparison of the peptides released from two proteins of animal origin in the context of infant digestion could give more knowledge using alternative protein sources as cow milk protein remain the main source in commercial infant formulas.
Fichier non déposé

Dates et versions

hal-03663472 , version 1 (10-05-2022)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

  • HAL Id : hal-03663472 , version 1

Citer

Mattia Casula, Olivia Ménard, Marie-Françoise Cochet, Didier Dupont, Simone Serrao, et al.. Untargeted peptidomics approach of sheep and goat infant formulas submitted to in vitro digestions. 7th International Conference on Food Digestion, May 2022, Cork, Ireland. , 2022. ⟨hal-03663472⟩

Collections

INRAE STLO
33 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More