Despite the essential role of specialized metabolites (SMs) in the interaction of plants with the environment,studying the ability of crop seeds to produce these protective compounds has been neglected. Furthermore,seeds produce a myriad of SMs, providing an interesting model to investigate their diversity and plasticity.Camelina sativagained a lot of interest in the past few years as a rustic oilseed crop. A characterization ofseed SM landscapes in six camelina genotypes grown in the field and harvested during five growing seasonshas been undertaken in this work. This allowed a comprehensive annotation of seed SMs combining analysesthat cluster SMs based on their chemical structures and co-accumulation patterns. These data showed broadeffects of the environment on the stimulation of the seed SM. Among well-annotated compounds, flavonolswere identified as the metabolic class characterized by high plasticity, revealing significant variable accumula-tion according to the year and/or the genotype. Lastly, a deeper characterization of primary metabolites andlipids in two selected genotypes has been performed. We showed that, in addition to flavonols, alkaloids andglucosinolates displayed a higher phenotypic plasticity with respect to most of the primary metabolites, inclu-ding some sugars and major storage compounds such as fatty acids, proteins and most lipid classes (e.g. dia-cylglycerols, triacylglycerols), but similar plasticity compared with free amino acids and carboxylic acids. Thiswork highlighted major and unexplored effects of the environment on the seed SM, demonstrating that seedsexhibit a dynamic and plastic metabolism, with an impact on seed quality.