To improve the protein autonomy and enrichment for animal welfare, the production of insects for animal feed is growing. Black soldier fly (Hermetia illucens) larvae (BSFL) are easily raised and can valorise co-products and food wastes. Besides a high nutrient content, BSFL contain compounds (chitin, lauric acid, antimicrobial peptides) of interest for gut microbiota and animal health. A wide variety of bacteria can cause diseases in poultry and foodborne illness in human. Avian coccidiosis is another highly prevalent disease, caused by Eimeria protozoan. Disease severity extends from morbidity to mortality. Its economic impact was recently reassessed to 13 billion $/year worldwide. The occurrence of antibacterial and coccidiostat drugs residues in animal-food products may promote (i) risk of allergic reactions by hypersensitive individuals, (ii) bad impact on the dynamics of gastrointestinal flora and (iii) the antibiotic resistance in gut bacteria. The steady increase of occurrence of bacteria resistant to multiple antibiotics has become a global public health threat that is driving the prudent use of antimicrobial in animals and the development of new alternatives. The aim of this study was to evaluate antimicrobial activities of BSFL extracts, comparing protein extracts solubilized in water and lipid extracts solubilized in methanol. We screened a library of bacterial strains that threaten livestock production (poultry, cattle, pigs) and against Eimeria tenella, responsible for avian cecal coccidiosis. Although protein extracts had no antibacterial activity, an inhibition of Eimeria development was observed at [0.001 - 0.01 g/L] of dry matter. The lipid extracts were efficient (0.7 - 5.66 g/L dry matter) against some strains of Pasteurella multocida, Corynebacterium bovis, Streptococcus suis, Riemerella anatipestifer and Trueperella pyogenes. They also inhibited Eimeria development at 0.6 mg/L dry matter. More research is needed to confirm those results in vivo: the antimicrobial effects of BSFL could improve the health and immune response of birds, when facing sanitary or environmental challenges.