Slaughter on the farm can address the concerns of farmers by meeting the needs of short distribution channels while better preserving animal welfare and meat quality. It can support conventional slaughter, by compensating for the significant decrease in the number of slaughterhouses in recent decades. The review describes first the different stages of slaughter and their possible impacts on animals’ stress, welfare and consequences on their meat quality. The second part takes stock of recent thinking on the subject of slaughter and the regulation and technological advances that have led to the development of mobile slaughter units. A non-exhaustive list of mobile slaughter units currently in use in different countries is presented. Although these units can only absorb a small percentage of the total amounts of animals slaughtered, they are a welcome alternative to current slaughter practices for certain types of production and distribution, provided that the animal welfare and all aspects of meat quality are garanteed.