An INFOGEST international consensus static in vitro digestion model adapted to the general older adult population and its application to dairy products - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Conference Papers Year : 2024

An INFOGEST international consensus static in vitro digestion model adapted to the general older adult population and its application to dairy products

Abstract

Understanding the mechanisms of food digestion is of paramount importance to determine the effect foods have on human health. Significant knowledge on the fate of food during digestion has been generated in healthy adults due to the development of physiologically-relevant in vitro digestion models. However, it appears that the performance of the oro-gastrointestinal tract is affected by ageing and that a model simulating the digestive conditions found in a younger adult (<65 y) is not relevant for an older adult (>65 y). The objectives of this work were: (1) to conduct an exhaustive literature search to find data on the physiological parameters of the older adult oro-gastrointestinal tract, (2) to define the parameters of an in vitro digestion model adapted to the older adult, (3) to apply it to the digestion of dairy products. International experts have discussed all the parameters during a dedicated workshop organized within the INFOGEST network. Data on food bolus properties collected in the older adult were gathered, including food particle size found in older adult boluses. In the stomach and small intestine, data suggest that significant physiological changes are observed between younger and older adults. In the latter, the rate of gastric emptying is slowed down, the pH of the stomach content is higher, the amount of secretions and thus the hydrolytic activities of gastric and intestinal digestive enzymes are reduced and the concentration of bile salts lower. The consensus in vitro digestion model of the older adult was applied to the digestion of 2 fermented dairy products formulated with a ratio of whey proteins to caseins of 80/20 and 20/80. Results showed that the digestion conditions used (young vs. older adult) influenced significantly the kinetics and extent of proteolysis in the gastric phase but not in the intestinal phase.
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hal-04546723 , version 1 (15-04-2024)

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Attribution - NonCommercial - ShareAlike

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  • HAL Id : hal-04546723 , version 1

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Didier Dupont, Anaïs Lavoisier, Olivia Ménard, Stefano Nebbia, Martine Morzel. An INFOGEST international consensus static in vitro digestion model adapted to the general older adult population and its application to dairy products. 8th International Conference on FOOD DIGESTION, Apr 2024, Porto, Portugal. ⟨hal-04546723⟩

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