Information processing circuits in cell-free systems: beyond gene expression regulation - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Conference Papers Year : 2023

Information processing circuits in cell-free systems: beyond gene expression regulation

Solassol Jerome
  • Function : Author

Abstract

Cell-free expression systems have emerged as promising tools for implementing information-processing circuits. Most of these circuits employ biosensors directly linked to gene expression regulation, using digital logic encoded on plasmid DNA. Here, we present several new approaches for building biological circuits that process information via metabolic transducers: combining analogue and digital logic in the metabolic perceptron, routing metabolic sensing through a common hub molecule, and screening transducer enzymes using linear DNA templates. The examples introduced here lay the groundwork for more advanced metabolic circuits for rapid and scalable multiplex sensing.
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Dates and versions

hal-04563028 , version 1 (29-04-2024)

Identifiers

  • HAL Id : hal-04563028 , version 1

Cite

Manish Kushwaha, Pandi Amir, Koch Mathilde, Soudier Paul, Batista Angelo Cardoso, et al.. Information processing circuits in cell-free systems: beyond gene expression regulation. International Conference on Engineering Synthetic Cells and Organelles, May 2023, Minneapolis, MN, USA, United States. ⟨hal-04563028⟩
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