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Ivermectin treatment in lactating mares results in suboptimal ivermectin exposure in their suckling foals

Abstract : The management of equine strongyles has become problematic over the last decade because of an increased prevalence of drug-resistant isolates worldwide. Therapeutic options are therefore limited, leaving macrocyclic lactones as the most often effective drug class. However, their lipophilic properties result in a long-lasting elimination that could favour drug resistance selection. As a result, ivermectin treatment in lactating mares could promote suboptimal exposure of their foal parasites to ivermectin, thereby selecting for more resistant worms. To test for this putative transfer, we selected two groups of six foal-mare pairs, one group of mares receiving ivermectin and the other being left untreated. We compared faecal egg count trajectories in foals from the two groups and quantified plasma ivermectin concentrations in ivermectin treated mares and their foals during seven days. Our results showed limited but sustained plasmatic exposure of foals associated with non-significant faecal egg count reduction (P = 0.69). This suggests that ivermectin treatment in lactating mares results in suboptimal exposure to the drug in their foal.
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https://hal.inrae.fr/hal-03282424
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Submitted on : Monday, July 12, 2021 - 12:41:48 PM
Last modification on : Monday, August 23, 2021 - 10:12:03 AM

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  •  Mayinda_Figure1.pdf    Embargoed until : 2022-01-12 
  •  Mayinda_supplementary_Figure1.pdf    Embargoed until : 2022-01-12 
  •  Mayinda_supplementary_Figure2.pdf    Embargoed until : 2022-01-12 
  •  Mayinda_Table 1.pdf    Embargoed until : 2022-01-12 
  •  Mayinda_Table 2.pdf    Embargoed until : 2022-01-12 

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Ghismon-De-Kasin Mayinda, Delphine Serreau, Amandine Gesbert, Fabrice Reigner, Jean-François Sutra, et al.. Ivermectin treatment in lactating mares results in suboptimal ivermectin exposure in their suckling foals. Veterinary Parasitology, Elsevier, In press, 296, 5 p. ⟨10.1016/j.vetpar.2021.109511⟩. ⟨hal-03282424⟩

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