The gut microbiota in retinal diseases - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Experimental Eye Research Year : 2022

The gut microbiota in retinal diseases


The gut microbiota is a complex ecosystem that inhabits the gastrointestinal tract and consists of archaea, fungi, viruses, and bacteria, with bacteria being dominant. From birth onwards, it coevolves dynamically together with the host. The composition of the gut microbiota is under the influence of a complex interplay between both host and environmental factors. Scientific advances in the past few decades have shown that it is essential in maintaining homeostasis and tipping the balance between health and disease. In addition to its role in food digestion, the gut microbiota is implicated in regulating multiple physiological processes in the host gut mucosa and in distant organs such as the brain. Persistent imbalance between gut microbial communities, termed "dysbiosis," has been associated with several inflammatory and metabolic diseases as well as with central nervous system disorders. In this review, we present the state of the art of current knowledge on an emerging concept, the microbiota-retina axis, and the potential role of its disturbance in the development of retinopathies. We also describe several microbiota-targeting strategies that could constitute preventive and therapeutic tools for retinopathies.
Fichier principal
Vignette du fichier
S0014483521004334.pdf (513.29 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03471216 , version 1 (05-01-2024)


Attribution - NonCommercial



Marie-Agnès Bringer, Pierre-Henry Gabrielle, Alain M Bron, Catherine Creuzot-Garcher, Niyazi Acar. The gut microbiota in retinal diseases. Experimental Eye Research, 2022, 214, pp.108867. ⟨10.1016/j.exer.2021.108867⟩. ⟨hal-03471216⟩
28 View
2 Download



Gmail Facebook X LinkedIn More