Large resource allocation models of cells - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Book Sections Year : 2023

Large resource allocation models of cells

Abstract

Resource balance analysis models are cell models based on three basic constraints formulated at genome-scale: stationary fluxes (balancing production and consumption fluxes, uptake and excretion fluxes, as well as compound dilution by cell growth); flux coupling constraints relating fluxes to the amounts of catalyzing enzymes (or other machines); and density constraints, limiting molecule amounts in cell compartments, or molecule concentrations. These constraints narrow down the solution space predicted by FBA towards more physiological solutions. Large resource allocation models build on the same principles, and have been implemented as different variations (RBA models in a narrow sense, ME-models, and pc-models).
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hal-04172144 , version 1 (27-07-2023)

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Hugo Dourado, Anne Goelzer, Pranas Grigaitis, Wolfram Liebermeister, Elad Noor. Large resource allocation models of cells. The Economic Cell Collective. Economic Principles in Cell Biology, , 2023, ⟨10.5281/zenodo.8156647⟩. ⟨hal-04172144⟩
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