The objective was to study associations among functional longevity and plasma indicators of metabolic adaption in Alpine goats during periparturient period. Two Alpine goat strains divergent for longevity (LGV+ and LGV-) were produced by AI selecting for extreme functional longevity but nondifferent milk yield. A total of 174 primiparous goats were studied in 2018, 2019, 2020 and 2021. Jugular plasma collected on wk -4, -3, -2, -1 relative to expected parturition, and wk 1, 2, 4, 13, 24, 33 of lactation was analysed for NEFA, BHB, glucose, urea and bilirubin. Data were analysed using SAS mixed models with repeated measures, including strain, litter size (LS), wk, and interactions as fixed effects, and year and goat (year) as random effects. Significant wk effects were observed for all metabolites. LGV- goats had greater plasma NEFA on wk-3 (181 vs 123 μM; strain × wk prepartum: P=0.05), and greater BHB prepartum (0.45 vs 0.41 mM; strain effect: P=0.04) than LGV+, which denotes greater fat mobilization and partial oxidation in late gestation LGV- goats. 35% of goats carried multiple foetus (LS2+) and LS not differ with LGV. Prepartum plasma NEFA, BHB and bilirubin were greater for LS2+ compared to single (LS1; P<0.001; 260 vs 174 μM; 0.51 vs 0.39 mM; 0.069 vs 0.056 mg/dl, respectively), whereas glucose was lower for LS2+ (P<0.001; 49.8 vs 54.7 mg/dl). Conversely, plasma NEFA was greater for LS1 during wk 1 and wk 2 postpartum (P<0.05; 558 vs 442 on wk 1, and 421 vs 330 μM on wk 2, respectively), reflecting greater availability of body reserves to support lactation in LS1. Prepartum incidence of BHB>0.80 mM was significantly greater for LS2+ than LS1 (30 vs 3.7%), and for LGV- carrying LS2+ than LGV+ carrying LS2+ (42 vs 17%). Marked LS effects were observed in plasma metabolite profiles in primiparous goats. LGV strains differ in their metabolic adaptations peripartum. This study has received funding from the EU H2020 research and innovation program under grant agreement No 772787 (SMARTER) and from APISGENE (ACTIVEGOAT)