Intra- and interindividual variability in fasted gastric content volume
Résumé
Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore,
the amount of gastric fluid present in a fasted state may influence subsequent digestion and
drug delivery. We aimed to describe intra- and interindividual variation in fasted gastric
content volume (FGCV) and to determine the association with age, sex, and body size
characteristics.
Methods: Data from 24 MRI studies measuring FGCV in healthy, mostly young individuals
after an overnight fast were pooled. Analysis included 366 participants with a total of 870
measurements. Linear mixed model analysis was performed to calculate intra- and
interindividual variability and to assess the effects of age, sex, weight, height, weight*height
as a proxy for body size, and body mass index (BMI).
Results: FGCV ranged from 0 to 156 mL, with a mean (± SD) value of 33 ± 25 mL. The
overall coefficient of variation within the study population was 75.6%, interindividual SD was
15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI
had no effect on FGCV. Women had lower volumes compared to men (MD: -6 mL), when
corrected for the aforementioned factors.
Conclusion: FGCV is highly variable, with higher intraindividual compared to interindividual
variability, indicating that FGCV is subject to day-to-day and within-day variation and is not a
stable personal characteristic. This highlights the importance of considering FGCV when
studying digestion and drug dissolution. Exact implications remain to be studied
Domaines
Alimentation et Nutrition
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification
