Early lactation is a period for oxidative stress and inflammation, which can lead to cell damage in dairy cows. Our objective was to investigate the influence of dietary supplementation of vitamin E or plant extracts, on redox and immune status of dairy cows. Forty-five Holstein cows, including 23 primiparous cows, were classified into 3 groups and followed from 3 weeks before to 12 weeks after calving. The 15 cows of the control group were fed an unsupplemented diet, the 16 cows in the vitamin E group received 3,000 IU/d 3 weeks before and 1,000 IU/d for 12 weeks after calving, and the 14 cows in the plant extract group received 10 g/d for 12 weeks after calving. Plasma redox status were analysed by spectrophotometry and HPLC methods. Plasma cytokines were analysed after an ex vivo challenge of whole-blood cells with heat-killed Escherichia coli. Blood neutrophils were analysed by flow cytometry to measure their production of reactive oxygen species under ex vivo stimulation. Data were analysed with a mixed model including supplementation, parity, week. Plasma α-tocopherol was higher in vitamin E group than in the other groups. Milk yield, plasma H2O2, plasma antioxidant capacity and plasma glutathione peroxidase activity were not influenced by the supplementations. Erythrocyte glutathione peroxidase activity tended to be higher and plasma malondialdehyde tended to be lower in vitamin E group than in the other groups. Vitamin E and plant extract groups had lower plasma concentrations of cytokines: CCL4 for plant extract group, IL-6 as a tendency for vitamin E group, and IL-8 for both antioxidant treatments. Both supplemented groups had lower MHCII+ neutrophil percentage, and lower ROS production than the control group. Our study showed that antioxidant nutritional strategies in healthy cows can affect the redox and immune status and may improve antioxidant capacities and reduce the inflammatory response.